The importance of ACE2 in regulating the cardiovascular system
A recently discovered homologue of the angiotensin-converting enzyme, ACE2, insensitive to ACE inhibitors, was found in rodents and humans. ACE2 is expressed mainly in the vasculature, heart and kidney. ACE2 removes a single amino acid of the carboxy terminal of peptides. In the renin-angiotensin-aldosterone system (RAAS), it is responsible for the conversion of angiotensin I (Ang I) and angiotensin II (Ang II) to Ang 1-9 and Ang 1-7, respectively. While ACE forms Ang II, a potent vasoconstrictor, ACE2 degrades this peptide to form Ang 1-7 which has an opposite action. Therefore, ACE2 counteracts ACE in the balance of vasopressor/vasodilator as well as heart and kidney function. The importance of ACE2 in physiological and pathophysiological conditions is unclear and is currently being studied.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:146 |
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| Enthalten in: |
Harefuah - 146(2007), 9 vom: 25. Sept., Seite 703-6, 733 |
| Sprache: |
Hebräisch |
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| Beteiligte Personen: |
Raz, Ayelet [VerfasserIn] |
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| Themen: |
ACE2 protein, human |
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| Anmerkungen: |
Date Completed 07.01.2008 Date Revised 09.12.2020 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM174698003 |
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| 245 | 1 | 4 | |a The importance of ACE2 in regulating the cardiovascular system |
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| 500 | |a Date Revised 09.12.2020 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A recently discovered homologue of the angiotensin-converting enzyme, ACE2, insensitive to ACE inhibitors, was found in rodents and humans. ACE2 is expressed mainly in the vasculature, heart and kidney. ACE2 removes a single amino acid of the carboxy terminal of peptides. In the renin-angiotensin-aldosterone system (RAAS), it is responsible for the conversion of angiotensin I (Ang I) and angiotensin II (Ang II) to Ang 1-9 and Ang 1-7, respectively. While ACE forms Ang II, a potent vasoconstrictor, ACE2 degrades this peptide to form Ang 1-7 which has an opposite action. Therefore, ACE2 counteracts ACE in the balance of vasopressor/vasodilator as well as heart and kidney function. The importance of ACE2 in physiological and pathophysiological conditions is unclear and is currently being studied | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Bogner, Ido |e verfasserin |4 aut | |
| 700 | 1 | |a Strigevsky, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Keidar, Shlomo |e verfasserin |4 aut | |
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