Effect of chromium supplementation on glucose metabolism and lipids : a systematic review of randomized controlled trials
OBJECTIVE: A systematic review of the effect of chromium supplementation on glucose metabolism and lipid levels.
RESEARCH DESIGN AND METHODS: A literature search was conducted in MEDLINE and the Commonwealth Agricultural Bureau. Eligible studies were English language randomized controlled trials of chromium supplement intake > or = 3 weeks, with > or = 10 participants receiving chromium. All trials with glucose metabolism outcomes and trials of individuals with diabetes or glucose intolerance for lipid outcomes were included. Meta-analyses were performed as appropriate.
RESULTS: Forty-one studies met criteria, almost half of which were of poor quality. Among participants with type 2 diabetes, chromium supplementation improved glycosylated hemoglobin levels by -0.6% (95% CI -0.9 to -0.2) and fasting glucose by -1.0 mmol/l (-1.4 to -0.5) but not lipids. There was no benefit in individuals without diabetes. There were some indications of dose effect and differences among chromium formulations. Larger effects were more commonly observed in poor-quality studies. The evidence was limited by poor study quality, heterogeneity in methodology and results, and a lack of consensus on assessment of chromium status.
CONCLUSIONS: No significant effect of chromium on lipid or glucose metabolism was found in people without diabetes. Chromium supplementation significantly improved glycemia among patients with diabetes. However, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation.
| Errataetall: |
CommentIn: Diabetes Care. 2007 Sep;30(9):e102; author reply e103. - PMID 17726181 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Diabetes care - 30(2007), 8 vom: 22. Aug., Seite 2154-63 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Balk, Ethan M [VerfasserIn] |
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| Themen: |
0R0008Q3JB |
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| Anmerkungen: |
Date Completed 04.10.2007 Date Revised 10.04.2022 published: Print-Electronic CommentIn: Diabetes Care. 2007 Sep;30(9):e102; author reply e103. - PMID 17726181 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM170448649 |
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| 100 | 1 | |a Balk, Ethan M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of chromium supplementation on glucose metabolism and lipids |b a systematic review of randomized controlled trials |
| 264 | 1 | |c 2007 | |
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| 500 | |a Date Completed 04.10.2007 | ||
| 500 | |a Date Revised 10.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Diabetes Care. 2007 Sep;30(9):e102; author reply e103. - PMID 17726181 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: A systematic review of the effect of chromium supplementation on glucose metabolism and lipid levels | ||
| 520 | |a RESEARCH DESIGN AND METHODS: A literature search was conducted in MEDLINE and the Commonwealth Agricultural Bureau. Eligible studies were English language randomized controlled trials of chromium supplement intake > or = 3 weeks, with > or = 10 participants receiving chromium. All trials with glucose metabolism outcomes and trials of individuals with diabetes or glucose intolerance for lipid outcomes were included. Meta-analyses were performed as appropriate | ||
| 520 | |a RESULTS: Forty-one studies met criteria, almost half of which were of poor quality. Among participants with type 2 diabetes, chromium supplementation improved glycosylated hemoglobin levels by -0.6% (95% CI -0.9 to -0.2) and fasting glucose by -1.0 mmol/l (-1.4 to -0.5) but not lipids. There was no benefit in individuals without diabetes. There were some indications of dose effect and differences among chromium formulations. Larger effects were more commonly observed in poor-quality studies. The evidence was limited by poor study quality, heterogeneity in methodology and results, and a lack of consensus on assessment of chromium status | ||
| 520 | |a CONCLUSIONS: No significant effect of chromium on lipid or glucose metabolism was found in people without diabetes. Chromium supplementation significantly improved glycemia among patients with diabetes. However, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
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| 650 | 7 | |a Chromium |2 NLM | |
| 650 | 7 | |a 0R0008Q3JB |2 NLM | |
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| 700 | 1 | |a Lichtenstein, Alice H |e verfasserin |4 aut | |
| 700 | 1 | |a Lau, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Pittas, Anastassios G |e verfasserin |4 aut | |
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