Occupational and genetic risk factors associated with intervertebral disc disease
STUDY DESIGN: Cross-sectional epidemiologic study.
OBJECTIVE: To evaluate the interaction between known genetic risk factors and whole-body vibration for symptomatic intervertebral disc disease (IDD) in an occupational sample.
SUMMARY OF BACKGROUND DATA: Risk factors of IDD include, among others, whole-body vibration and heredity. In this study, the importance of a set of known genetic risk factors and whole-body vibration was evaluated in an occupational sample of train engineers and sedentary controls.
METHODS: Eleven variations in 8 genes (COL9A2, COL9A3, COL11A2, IL1A, IL1B, IL6, MMP-3, and VDR) were genotyped in 150 male train engineers with an average of 21-year exposure to whole-body vibration and 61 male paper mill workers with no exposure to vibration. Subjects were classified into IDD-phenotype and asymptomatic groups, based on the latent class analysis.
RESULTS: The number of individuals belonging to the IDD-phenotype was significantly higher among train engineers (42% of train engineers vs. 17.5% of sedentary workers; P = 0.005). IL1A -889T allele represented a significant risk factor for the IDD-phenotype both in the single marker allelic association test (P = 0.043) and in the logistic regression analysis (P = 0.01). None of the other allele markers was significantly associated with symptoms when analyzed independently. However, for all the SNP markers considered, whole-body vibration represents a nominally significant risk factor.
CONCLUSION: The results suggest that whole-body vibration is a risk factor for symptomatic IDD. Moreover, whole-body vibration had an additive effect with genetic risk factors increasing the likelihood of belonging to the IDD-phenotype group. Of the independent genetic markers, IL1A -889T allele had strongest association with IDD-phenotype.
| Errataetall: |
CommentIn: Spine (Phila Pa 1976). 2007 Dec 1;32(25):2926; author reply 2926-7. - PMID 18246021 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Spine - 32(2007), 10 vom: 01. Mai, Seite 1129-34 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Virtanen, Iita M [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 23.05.2007 Date Revised 17.11.2011 published: Print CommentIn: Spine (Phila Pa 1976). 2007 Dec 1;32(25):2926; author reply 2926-7. - PMID 18246021 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM170007707 |
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| 245 | 1 | 0 | |a Occupational and genetic risk factors associated with intervertebral disc disease |
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| 500 | |a Date Revised 17.11.2011 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Spine (Phila Pa 1976). 2007 Dec 1;32(25):2926; author reply 2926-7. - PMID 18246021 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a STUDY DESIGN: Cross-sectional epidemiologic study | ||
| 520 | |a OBJECTIVE: To evaluate the interaction between known genetic risk factors and whole-body vibration for symptomatic intervertebral disc disease (IDD) in an occupational sample | ||
| 520 | |a SUMMARY OF BACKGROUND DATA: Risk factors of IDD include, among others, whole-body vibration and heredity. In this study, the importance of a set of known genetic risk factors and whole-body vibration was evaluated in an occupational sample of train engineers and sedentary controls | ||
| 520 | |a METHODS: Eleven variations in 8 genes (COL9A2, COL9A3, COL11A2, IL1A, IL1B, IL6, MMP-3, and VDR) were genotyped in 150 male train engineers with an average of 21-year exposure to whole-body vibration and 61 male paper mill workers with no exposure to vibration. Subjects were classified into IDD-phenotype and asymptomatic groups, based on the latent class analysis | ||
| 520 | |a RESULTS: The number of individuals belonging to the IDD-phenotype was significantly higher among train engineers (42% of train engineers vs. 17.5% of sedentary workers; P = 0.005). IL1A -889T allele represented a significant risk factor for the IDD-phenotype both in the single marker allelic association test (P = 0.043) and in the logistic regression analysis (P = 0.01). None of the other allele markers was significantly associated with symptoms when analyzed independently. However, for all the SNP markers considered, whole-body vibration represents a nominally significant risk factor | ||
| 520 | |a CONCLUSION: The results suggest that whole-body vibration is a risk factor for symptomatic IDD. Moreover, whole-body vibration had an additive effect with genetic risk factors increasing the likelihood of belonging to the IDD-phenotype group. Of the independent genetic markers, IL1A -889T allele had strongest association with IDD-phenotype | ||
| 650 | 4 | |a Journal Article | |
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