Innate response to self-antigen significantly exacerbates burn wound depth
A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2007 |
|---|---|
| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
|---|---|
| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 104(2007), 10 vom: 06. März, Seite 3973-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suber, Freeman [VerfasserIn] |
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| Themen: |
128559-51-3 |
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| Anmerkungen: |
Date Completed 24.04.2007 Date Revised 08.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM168976773 |
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| 245 | 1 | 0 | |a Innate response to self-antigen significantly exacerbates burn wound depth |
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| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 7 | |a Autoantigens |2 NLM | |
| 650 | 7 | |a Complement C4 |2 NLM | |
| 650 | 7 | |a Homeodomain Proteins |2 NLM | |
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| 700 | 1 | |a Carroll, Michael C |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Francis D |c Jr |e verfasserin |4 aut | |
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