Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats
BACKGROUND: Tacrolimus (FK506) is an immunosuppressive agent used in clinical transplantation. We studied the acute impact of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats.
METHODS: The animals injected with FK506 (2 mg/kg) subcutaneously were sacrificed at 12, 24, or 48 hours after administration. CD3(+), CD4(+) and CD8(+) T-cell populations in peripheral blood and spleen were analyzed by FACS.
RESULTS: After treatment with FK506, the proportion of CD4(+) cells significantly increased in the spleen at 12 hours, decreasing to control levels at 24 and 48 hours. There was a slight increase in the CD4(+) subpopulation in the peripheral blood at 12 and 24 hours and a significant increase at 48 hours. The CD8(+) T-cell subpopulations in peripheral blood and spleen were stable during FK506 administration.
CONCLUSIONS: These results indicated that FK506 increased CD4(+) spleen lymphocyte activation in a short time, inducing a subsequent increase in CD4(+) cells subsets in peripheral blood.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Transplantation proceedings - 39(2007), 1 vom: 01. Jan., Seite 292-4 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, M [VerfasserIn] |
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| Themen: |
CD3 Complex |
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| Anmerkungen: |
Date Completed 03.04.2007 Date Revised 16.11.2017 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM168178443 |
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| 100 | 1 | |a Wang, M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats |
| 264 | 1 | |c 2007 | |
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| 500 | |a Date Completed 03.04.2007 | ||
| 500 | |a Date Revised 16.11.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Tacrolimus (FK506) is an immunosuppressive agent used in clinical transplantation. We studied the acute impact of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats | ||
| 520 | |a METHODS: The animals injected with FK506 (2 mg/kg) subcutaneously were sacrificed at 12, 24, or 48 hours after administration. CD3(+), CD4(+) and CD8(+) T-cell populations in peripheral blood and spleen were analyzed by FACS | ||
| 520 | |a RESULTS: After treatment with FK506, the proportion of CD4(+) cells significantly increased in the spleen at 12 hours, decreasing to control levels at 24 and 48 hours. There was a slight increase in the CD4(+) subpopulation in the peripheral blood at 12 and 24 hours and a significant increase at 48 hours. The CD8(+) T-cell subpopulations in peripheral blood and spleen were stable during FK506 administration | ||
| 520 | |a CONCLUSIONS: These results indicated that FK506 increased CD4(+) spleen lymphocyte activation in a short time, inducing a subsequent increase in CD4(+) cells subsets in peripheral blood | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a CD3 Complex |2 NLM | |
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| 700 | 1 | |a Li, N |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Q |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, J |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Q |e verfasserin |4 aut | |
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