Vitamin B6, B12, and folic acid supplementation and cognitive function : a systematic review of randomized trials
BACKGROUND: Despite their important role in cognitive function, the value of B vitamin supplementation is unknown. A systematic review of the effect of pyridoxine hydrochloride (hereinafter "vitamin B(6)"), cyanocobalamin or hydroxycobalamin (hereinafter "vitamin B(12)"), and folic acid supplementation on cognitive function was performed.
METHODS: Literature search conducted in MEDLINE with supplemental articles from reviews and domain experts. We included English language randomized controlled trials of vitamins B(6) and/or B(12) and/or folic acid supplementation with cognitive function outcomes.
RESULTS: Fourteen trials met our criteria; most were of low quality and limited applicability. Approximately 50 different cognitive function tests were assessed. Three trials of vitamin B(6) and 6 of vitamin B(12) found no effect overall in a variety of doses, routes of administration, and populations. One of 3 trials of folic acid found a benefit in cognitive function in people with cognitive impairment and low baseline serum folate levels. Six trials of combinations of the B vitamins all concluded that the interventions had no effect on cognitive function. Among 3 trials, those in the placebo arm had greater improvements in a small number of cognitive tests than participants receiving either folic acid or combination B-vitamin supplements. The evidence was limited by a sparsity of studies, small sample size, heterogeneity in outcomes, and a lack of studies that evaluated symptoms or clinical outcomes.
CONCLUSION: The evidence does not yet provide adequate evidence of an effect of vitamin B(6) or B(12) or folic acid supplementation, alone or in combination, on cognitive function testing in people with either normal or impaired cognitive function.
| Errataetall: |
CommentIn: Arch Intern Med. 2007 Jul 23;167(14):1555; author reply 1555. - PMID 17646615 |
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| Medienart: |
Artikel |
| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:167 |
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| Enthalten in: |
Archives of internal medicine - 167(2007), 1 vom: 08. Jan., Seite 21-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Balk, Ethan M [VerfasserIn] |
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| Themen: |
12001-76-2 |
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| Anmerkungen: |
Date Completed 25.01.2007 Date Revised 01.12.2018 published: Print CommentIn: Arch Intern Med. 2007 Jul 23;167(14):1555; author reply 1555. - PMID 17646615 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM167582860 |
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| 100 | 1 | |a Balk, Ethan M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vitamin B6, B12, and folic acid supplementation and cognitive function |b a systematic review of randomized trials |
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| 500 | |a Date Revised 01.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Arch Intern Med. 2007 Jul 23;167(14):1555; author reply 1555. - PMID 17646615 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Despite their important role in cognitive function, the value of B vitamin supplementation is unknown. A systematic review of the effect of pyridoxine hydrochloride (hereinafter "vitamin B(6)"), cyanocobalamin or hydroxycobalamin (hereinafter "vitamin B(12)"), and folic acid supplementation on cognitive function was performed | ||
| 520 | |a METHODS: Literature search conducted in MEDLINE with supplemental articles from reviews and domain experts. We included English language randomized controlled trials of vitamins B(6) and/or B(12) and/or folic acid supplementation with cognitive function outcomes | ||
| 520 | |a RESULTS: Fourteen trials met our criteria; most were of low quality and limited applicability. Approximately 50 different cognitive function tests were assessed. Three trials of vitamin B(6) and 6 of vitamin B(12) found no effect overall in a variety of doses, routes of administration, and populations. One of 3 trials of folic acid found a benefit in cognitive function in people with cognitive impairment and low baseline serum folate levels. Six trials of combinations of the B vitamins all concluded that the interventions had no effect on cognitive function. Among 3 trials, those in the placebo arm had greater improvements in a small number of cognitive tests than participants receiving either folic acid or combination B-vitamin supplements. The evidence was limited by a sparsity of studies, small sample size, heterogeneity in outcomes, and a lack of studies that evaluated symptoms or clinical outcomes | ||
| 520 | |a CONCLUSION: The evidence does not yet provide adequate evidence of an effect of vitamin B(6) or B(12) or folic acid supplementation, alone or in combination, on cognitive function testing in people with either normal or impaired cognitive function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
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| 700 | 1 | |a Tatsioni, Athina |e verfasserin |4 aut | |
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| 700 | 1 | |a Lau, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenberg, Irwin H |e verfasserin |4 aut | |
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