EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responses
Alloreactive T cells play a key role in mediating graft-vs-host disease and allograft rejection, and recent data suggest that most T cell alloreactivity resides within the CD4 T cell subset. Particularly, T cell responses to herpesvirus can shape the alloreactive repertoire and influence transplantation outcomes. In this study, we describe six distinct EBV-specific CD4(+) T cell clones that cross-reacted with EBV-transformed lymphoblastoid cell lines (LCLs), dendritic cells, and endothelial cells expressing MHC class II alleles commonly found in the population. Allorecognition showed exquisite MHC specificity. These CD4(+) T cell clones efficiently killed dendritic cells or LCLs expressing the cross-reactive allogeneic MHC class II molecules, whereas they did not kill autologous LCLs. Endothelial cells expressing the proper allogeneic MHC molecules were poorly killed, but they induced high-level TNF-alpha production by the EBV-specific CD4(+) T cell clones. As already proposed, the strong alloreactivity toward LCLs suggest that these cells could be used for selective depletion of alloreactive T cells.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2006 |
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| Erschienen: |
2006 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:177 |
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| Enthalten in: |
Journal of immunology (Baltimore, Md. : 1950) - 177(2006), 3 vom: 01. Aug., Seite 1427-33 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Landais, Elise [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 06.09.2006 Date Revised 16.05.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM164213937 |
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| 245 | 1 | 0 | |a EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responses |
| 264 | 1 | |c 2006 | |
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| 500 | |a Date Completed 06.09.2006 | ||
| 500 | |a Date Revised 16.05.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Alloreactive T cells play a key role in mediating graft-vs-host disease and allograft rejection, and recent data suggest that most T cell alloreactivity resides within the CD4 T cell subset. Particularly, T cell responses to herpesvirus can shape the alloreactive repertoire and influence transplantation outcomes. In this study, we describe six distinct EBV-specific CD4(+) T cell clones that cross-reacted with EBV-transformed lymphoblastoid cell lines (LCLs), dendritic cells, and endothelial cells expressing MHC class II alleles commonly found in the population. Allorecognition showed exquisite MHC specificity. These CD4(+) T cell clones efficiently killed dendritic cells or LCLs expressing the cross-reactive allogeneic MHC class II molecules, whereas they did not kill autologous LCLs. Endothelial cells expressing the proper allogeneic MHC molecules were poorly killed, but they induced high-level TNF-alpha production by the EBV-specific CD4(+) T cell clones. As already proposed, the strong alloreactivity toward LCLs suggest that these cells could be used for selective depletion of alloreactive T cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Isoantigens |2 NLM | |
| 700 | 1 | |a Morice, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Heather M |e verfasserin |4 aut | |
| 700 | 1 | |a Haigh, Tracey A |e verfasserin |4 aut | |
| 700 | 1 | |a Charreau, Béatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Bonneville, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Graham S |e verfasserin |4 aut | |
| 700 | 1 | |a Houssaint, Elisabeth |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of immunology (Baltimore, Md. : 1950) |d 1945 |g 177(2006), 3 vom: 01. Aug., Seite 1427-33 |w (DE-627)NLM000018554 |x 1550-6606 |7 nnns |
| 773 | 1 | 8 | |g volume:177 |g year:2006 |g number:3 |g day:01 |g month:08 |g pages:1427-33 |
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| 951 | |a AR | ||
| 952 | |d 177 |j 2006 |e 3 |b 01 |c 08 |h 1427-33 | ||