Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction
Our previous studies demonstrated that the psychostimulant methamphetamine (MA) and the human immunodeficiency virus-1 (HIV-1) protein Tat interacted to cause enhanced dopaminergic neurotoxicity. The present study examined whether tumor necrosis factor-alpha (TNF-alpha) mediates the interaction between Tat and MA. In Sprague-Dawley rats, injections of Tat caused a small but significant increase in striatal TNF-alpha level, whereas MA resulted in no change. The increase in TNF-alpha induced by Tat + MA was not significantly different from that induced by Tat alone. Temporal analysis of TNF-alpha levels revealed a 50-fold increase 4 h after Tat administration. In C57BL/6 mice, Tat + MA induced a 50% decline in striatal dopamine levels, which was significantly attenuated in mice lacking both receptors for TNF-alpha. TNF-alpha synthesis inhibitors significantly attenuated Tat + MA neurotoxicity in hippocampal neuronal culture. The results suggest that Tat-induced elevation of TNF-alpha may predispose the dopaminergic terminals to subsequent damage by MA.
Medienart: |
Artikel |
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Erscheinungsjahr: |
2006 |
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Erschienen: |
2006 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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Enthalten in: |
Neurobiology of disease - 23(2006), 3 vom: 15. Sept., Seite 663-8 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Theodore, Shaji [VerfasserIn] |
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Anmerkungen: |
Date Completed 01.11.2006 Date Revised 21.11.2013 published: Print-Electronic Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM16401442X |
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100 | 1 | |a Theodore, Shaji |e verfasserin |4 aut | |
245 | 1 | 0 | |a Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction |
264 | 1 | |c 2006 | |
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500 | |a Date Completed 01.11.2006 | ||
500 | |a Date Revised 21.11.2013 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Our previous studies demonstrated that the psychostimulant methamphetamine (MA) and the human immunodeficiency virus-1 (HIV-1) protein Tat interacted to cause enhanced dopaminergic neurotoxicity. The present study examined whether tumor necrosis factor-alpha (TNF-alpha) mediates the interaction between Tat and MA. In Sprague-Dawley rats, injections of Tat caused a small but significant increase in striatal TNF-alpha level, whereas MA resulted in no change. The increase in TNF-alpha induced by Tat + MA was not significantly different from that induced by Tat alone. Temporal analysis of TNF-alpha levels revealed a 50-fold increase 4 h after Tat administration. In C57BL/6 mice, Tat + MA induced a 50% decline in striatal dopamine levels, which was significantly attenuated in mice lacking both receptors for TNF-alpha. TNF-alpha synthesis inhibitors significantly attenuated Tat + MA neurotoxicity in hippocampal neuronal culture. The results suggest that Tat-induced elevation of TNF-alpha may predispose the dopaminergic terminals to subsequent damage by MA | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 7 | |a Dopamine Uptake Inhibitors |2 NLM | |
650 | 7 | |a Gene Products, tat |2 NLM | |
650 | 7 | |a Protein Synthesis Inhibitors |2 NLM | |
650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
650 | 7 | |a tat Gene Products, Human Immunodeficiency Virus |2 NLM | |
650 | 7 | |a Methamphetamine |2 NLM | |
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650 | 7 | |a Dopamine |2 NLM | |
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700 | 1 | |a Cass, Wayne A |e verfasserin |4 aut | |
700 | 1 | |a Nath, Avindra |e verfasserin |4 aut | |
700 | 1 | |a Steiner, Joseph |e verfasserin |4 aut | |
700 | 1 | |a Young, Kristie |e verfasserin |4 aut | |
700 | 1 | |a Maragos, William F |e verfasserin |4 aut | |
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