Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice
Moderate physical exercise (PE) combined with metabolic treatment (MT) (antioxidants and l-arginine) are well known to reduce atherosclerotic lesion formation in hypercholesterolemic mice. However, the long-term beneficial effects on unstable atheroma remain poorly understood. We started early PE training in large groups of 6-week-old hypercholesterolemic mice (by graduated swimming) alone or in combination with nutritional supplementation (1.0% vitamin E added to the chow and 0.05% vitamin C and 6% l-arginine added to the drinking water). Inactive controls did not receive PE. The spontaneous development of atherosclerotic plaque rupture (associated with advanced atherosclerosis) and survival rates were evaluated. Moderate PE elicited an increase in plasma levels of nitric oxide. Early combined treatment with PE and MT in the hypercholesterolemic mice significantly reduced lesions (also detected noninvasively at 10 months) and spontaneous atherosclerotic plaque rupture and prolonged survival more effectively than each intervention alone. Thus, early concerted actions of MT and PE improve the natural history of atherosclerotic lesions and reduce the plaque instability in hypercholesterolemic mice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2006 |
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| Erschienen: |
2006 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:103 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 103(2006), 27 vom: 05. Juli, Seite 10479-10484 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Napoli, Claudio [VerfasserIn] |
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| Links: |
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| Themen: |
EC 1.14.13.39 |
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| Anmerkungen: |
Date Completed 16.08.2006 Date Revised 13.11.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1073/pnas.0602774103 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM163761272 |
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| 100 | 1 | |a Napoli, Claudio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice |
| 264 | 1 | |c 2006 | |
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| 500 | |a Date Completed 16.08.2006 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Moderate physical exercise (PE) combined with metabolic treatment (MT) (antioxidants and l-arginine) are well known to reduce atherosclerotic lesion formation in hypercholesterolemic mice. However, the long-term beneficial effects on unstable atheroma remain poorly understood. We started early PE training in large groups of 6-week-old hypercholesterolemic mice (by graduated swimming) alone or in combination with nutritional supplementation (1.0% vitamin E added to the chow and 0.05% vitamin C and 6% l-arginine added to the drinking water). Inactive controls did not receive PE. The spontaneous development of atherosclerotic plaque rupture (associated with advanced atherosclerosis) and survival rates were evaluated. Moderate PE elicited an increase in plasma levels of nitric oxide. Early combined treatment with PE and MT in the hypercholesterolemic mice significantly reduced lesions (also detected noninvasively at 10 months) and spontaneous atherosclerotic plaque rupture and prolonged survival more effectively than each intervention alone. Thus, early concerted actions of MT and PE improve the natural history of atherosclerotic lesions and reduce the plaque instability in hypercholesterolemic mice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 7 | |a Nitric Oxide Synthase Type III |2 NLM | |
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| 700 | 1 | |a Williams-Ignarro, Sharon |e verfasserin |4 aut | |
| 700 | 1 | |a de Nigris, Filomena |e verfasserin |4 aut | |
| 700 | 1 | |a Lerman, Lilach O |e verfasserin |4 aut | |
| 700 | 1 | |a D'Armiento, Francesco P |e verfasserin |4 aut | |
| 700 | 1 | |a Crimi, Ettore |e verfasserin |4 aut | |
| 700 | 1 | |a Byrns, Russell E |e verfasserin |4 aut | |
| 700 | 1 | |a Casamassimi, Amelia |e verfasserin |4 aut | |
| 700 | 1 | |a Lanza, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Gombos, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Sica, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Ignarro, Louis J |e verfasserin |4 aut | |
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