Connective tissue diseases and cardiac rhythm disorders : an overview
Cardiovascular involvement is common in connective tissue diseases (CTD), with relevant implications in terms of morbidity and mortality. Rhythm disturbances, i.e. conduction defects and tachyarrhythmias, represent a frequent clinical manifestation of CTD-associated cardiovascular damage and a possible cause of sudden death. The underlying arrhythmogenic mechanisms are probably multiple and intriguing, even though the myocardial fibrosis frequently observed at the pathological examination seems to play a pivotal role. Myocardial fibrosis is produced directly by inflammatory processes, or indirectly as a consequence of coronary artery occlusive disease, and it may affect the conduction system also representing the pathological substrate for reentry circles. An overview of CTD-associated cardiac rhythm disturbances is here provided. Among CTD-associated rhythm disorders, congenital heart block (CHB), which represents the main feature of neonatal lupus, a rare syndrome related to the transplacental passage of autoantibodies from anti-Ro/SSA-positive mother to their newborns, seems to acknowledge a peculiar mechanism of disease possibly dependent on a direct arrhythmogenicity of anti-Ro/SSA antibodies. Moreover, new anti-Ro/SSA-associated EKG abnormalities have been recently described in children (sinus bradycardia and corrected QT (QTc) interval prolongation) as well as in adults (QTc interval prolongation).
Medienart: |
Artikel |
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Erscheinungsjahr: |
2006 |
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Erschienen: |
2006 |
Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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Enthalten in: |
Autoimmunity reviews - 5(2006), 5 vom: 30. Mai, Seite 306-13 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Lazzerini, Pietro Enea [VerfasserIn] |
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Themen: |
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Anmerkungen: |
Date Completed 12.09.2006 Date Revised 08.04.2022 published: Print-Electronic Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM163585288 |
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245 | 1 | 0 | |a Connective tissue diseases and cardiac rhythm disorders |b an overview |
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520 | |a Cardiovascular involvement is common in connective tissue diseases (CTD), with relevant implications in terms of morbidity and mortality. Rhythm disturbances, i.e. conduction defects and tachyarrhythmias, represent a frequent clinical manifestation of CTD-associated cardiovascular damage and a possible cause of sudden death. The underlying arrhythmogenic mechanisms are probably multiple and intriguing, even though the myocardial fibrosis frequently observed at the pathological examination seems to play a pivotal role. Myocardial fibrosis is produced directly by inflammatory processes, or indirectly as a consequence of coronary artery occlusive disease, and it may affect the conduction system also representing the pathological substrate for reentry circles. An overview of CTD-associated cardiac rhythm disturbances is here provided. Among CTD-associated rhythm disorders, congenital heart block (CHB), which represents the main feature of neonatal lupus, a rare syndrome related to the transplacental passage of autoantibodies from anti-Ro/SSA-positive mother to their newborns, seems to acknowledge a peculiar mechanism of disease possibly dependent on a direct arrhythmogenicity of anti-Ro/SSA antibodies. Moreover, new anti-Ro/SSA-associated EKG abnormalities have been recently described in children (sinus bradycardia and corrected QT (QTc) interval prolongation) as well as in adults (QTc interval prolongation) | ||
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700 | 1 | |a Galeazzi, Mauro |e verfasserin |4 aut | |
700 | 1 | |a Laghi Pasini, Franco |e verfasserin |4 aut | |
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