Cachexia : pathophysiology and clinical relevance
Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess myostatin, and excess glucocorticoids. Numerous diseases can result in cachexia, each by a slightly different mechanism. Both nutritional support and orexigenic agents play a role in the management of cachexia.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2006 |
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| Erschienen: |
2006 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:83 |
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| Enthalten in: |
The American journal of clinical nutrition - 83(2006), 4 vom: 05. Apr., Seite 735-43 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Morley, John E [VerfasserIn] |
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| Anmerkungen: |
Date Completed 18.05.2006 Date Revised 18.03.2023 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM161879969 |
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| 100 | 1 | |a Morley, John E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cachexia |b pathophysiology and clinical relevance |
| 264 | 1 | |c 2006 | |
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| 500 | |a Date Completed 18.05.2006 | ||
| 500 | |a Date Revised 18.03.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess myostatin, and excess glucocorticoids. Numerous diseases can result in cachexia, each by a slightly different mechanism. Both nutritional support and orexigenic agents play a role in the management of cachexia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Glucocorticoids |2 NLM | |
| 650 | 7 | |a MSTN protein, human |2 NLM | |
| 650 | 7 | |a Myostatin |2 NLM | |
| 650 | 7 | |a Transforming Growth Factor beta |2 NLM | |
| 650 | 7 | |a Testosterone |2 NLM | |
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| 700 | 1 | |a Thomas, David R |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Margaret-Mary G |e verfasserin |4 aut | |
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