Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia : a pilot case-control association study in an Italian sample
Copyright 2006 Wiley-Liss, Inc..
Glutamatergic dysfunction is one of the major hypotheses for the pathogenesis of schizophrenia. The GRIA1 gene encodes for one (GluR1) of the four (GluR1-4) ionotropic AMPA receptor subunits. GRIA1 is a good candidate gene for susceptibility to schizophrenia since it maps in 5q33, a region where the presence of susceptibility loci has been suggested by independent genome-wide scans and because its expression has been found to be decreased in the brain of some schizophrenia patients. We present data from a case-control association study on the Italian population with eight polymorphisms spanning the whole GRIA1 gene. Single-locus analysis revealed a significantly different allele distribution in cases and in controls of two SNPs (rs707176, 0.41 vs. 0.31, P = 0.009; rs2963944, 0.41 vs. 0.30, P = 0.007), and one microsatellite (rs10631988, allele 9: 0.40 vs. 0.29, P = 0.004). Haplotype analysis showed an increased frequency of a specific haplotype for these markers (C09CC, 0.39 vs. 0.28, P = 0.009). Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2006 |
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| Erschienen: |
2006 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:141B |
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| Enthalten in: |
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 141B(2006), 3 vom: 05. Apr., Seite 287-93 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Magri, Chiara [VerfasserIn] |
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| Themen: |
Glutamate receptor ionotropic, AMPA 1 |
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| Anmerkungen: |
Date Completed 30.05.2006 Date Revised 30.09.2020 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM161168159 |
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| 245 | 1 | 0 | |a Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia |b a pilot case-control association study in an Italian sample |
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| 500 | |a Date Completed 30.05.2006 | ||
| 500 | |a Date Revised 30.09.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright 2006 Wiley-Liss, Inc. | ||
| 520 | |a Glutamatergic dysfunction is one of the major hypotheses for the pathogenesis of schizophrenia. The GRIA1 gene encodes for one (GluR1) of the four (GluR1-4) ionotropic AMPA receptor subunits. GRIA1 is a good candidate gene for susceptibility to schizophrenia since it maps in 5q33, a region where the presence of susceptibility loci has been suggested by independent genome-wide scans and because its expression has been found to be decreased in the brain of some schizophrenia patients. We present data from a case-control association study on the Italian population with eight polymorphisms spanning the whole GRIA1 gene. Single-locus analysis revealed a significantly different allele distribution in cases and in controls of two SNPs (rs707176, 0.41 vs. 0.31, P = 0.009; rs2963944, 0.41 vs. 0.30, P = 0.007), and one microsatellite (rs10631988, allele 9: 0.40 vs. 0.29, P = 0.004). Haplotype analysis showed an increased frequency of a specific haplotype for these markers (C09CC, 0.39 vs. 0.28, P = 0.009). Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Receptors, AMPA |2 NLM | |
| 650 | 7 | |a glutamate receptor ionotropic, AMPA 1 |2 NLM | |
| 650 | 7 | |a TFZ3H25BS1 |2 NLM | |
| 700 | 1 | |a Gardella, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Barlati, Stefano Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Podavini, Damiano |e verfasserin |4 aut | |
| 700 | 1 | |a Iatropoulos, Paraskevas |e verfasserin |4 aut | |
| 700 | 1 | |a Bonomi, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Valsecchi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Sacchetti, Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Barlati, Sergio |e verfasserin |4 aut | |
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