Gene therapy in cancer : the missing point
Over the last century cancer research has produced data leading to a composite picture where gene mutations and epigenetic phenomena strictly relate and overlap. This complexity has repercussions on the anti-cancer therapeutical strategies. The therapeutic pathway paved by the kochian one-cause/one disease principle fails in front of a multigenic multiphenomena disease like cancer. We still do not know what target(s) to hit/modify in order to prevent/stop the carcinogenic progression. On the light of cancer statistics 2005, we discuss the need of exactly defining the cancer targets in order to exploit the high potential of gene therapy.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Journal of experimental therapeutics & oncology - 5(2005), 2 vom: 09., Seite 151-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kanduc, Darja [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 02.03.2006 Date Revised 15.11.2012 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM160649897 |
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| 245 | 1 | 0 | |a Gene therapy in cancer |b the missing point |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Over the last century cancer research has produced data leading to a composite picture where gene mutations and epigenetic phenomena strictly relate and overlap. This complexity has repercussions on the anti-cancer therapeutical strategies. The therapeutic pathway paved by the kochian one-cause/one disease principle fails in front of a multigenic multiphenomena disease like cancer. We still do not know what target(s) to hit/modify in order to prevent/stop the carcinogenic progression. On the light of cancer statistics 2005, we discuss the need of exactly defining the cancer targets in order to exploit the high potential of gene therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Geliebter, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Lucchese, Alberta |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzanti, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Mittelman, Abraham |e verfasserin |4 aut | |
| 700 | 1 | |a Polimeno, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Ponzetto, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Santacroce, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Simone, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Sinigaglia, Eberta |e verfasserin |4 aut | |
| 700 | 1 | |a Sinha, Animesh A |e verfasserin |4 aut | |
| 700 | 1 | |a Tessitore, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Tiwari, Raj K |e verfasserin |4 aut | |
| 700 | 1 | |a Farber, Emanuel |e verfasserin |4 aut | |
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