Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma : possible regulator of insitu steroidogenesis
Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3beta-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2006 |
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| Erschienen: |
2006 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:244 |
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| Enthalten in: |
Cancer letters - 244(2006), 1 vom: 28. Nov., Seite 24-33 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Miki, Yasuhiro [VerfasserIn] |
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| Anmerkungen: |
Date Completed 25.01.2007 Date Revised 20.11.2014 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM160241367 |
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| 100 | 1 | |a Miki, Yasuhiro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma |b possible regulator of insitu steroidogenesis |
| 264 | 1 | |c 2006 | |
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| 500 | |a Date Completed 25.01.2007 | ||
| 500 | |a Date Revised 20.11.2014 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3beta-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a DNA-Binding Proteins |2 NLM | |
| 650 | 7 | |a NR5A2 protein, human |2 NLM | |
| 650 | 7 | |a Neoplasm Proteins |2 NLM | |
| 650 | 7 | |a Phosphoproteins |2 NLM | |
| 650 | 7 | |a Receptors, Cytoplasmic and Nuclear |2 NLM | |
| 650 | 7 | |a Transcription Factors |2 NLM | |
| 650 | 7 | |a steroidogenic acute regulatory protein |2 NLM | |
| 650 | 7 | |a Receptor, ErbB-2 |2 NLM | |
| 650 | 7 | |a EC 2.7.10.1 |2 NLM | |
| 700 | 1 | |a Clyne, Colin D |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Moriya, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Shibuya, Rie |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ishida, Takanori |e verfasserin |4 aut | |
| 700 | 1 | |a Yabuki, Nami |e verfasserin |4 aut | |
| 700 | 1 | |a Kitada, Kunio |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Shin-Ichi |e verfasserin |4 aut | |
| 700 | 1 | |a Sasano, Hironobu |e verfasserin |4 aut | |
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