Treatment of non-dipper hypertension with bedtime administration of valsartan
BACKGROUND: Previous results have indicated that valsartan administration at bedtime, as opposed to upon wakening, may improve the diurnal: nocturnal ratio of blood pressure without loss in 24-h coverage and efficacy.
OBJECTIVES: To investigate the administration time-dependent antihypertensive efficacy of valsartan in non-dipper patients.
METHODS: We studied 148 non-dipper patients with grade 1-2 essential hypertension, aged 53.0+/-12.6 years, who were randomly assigned to receive valsartan (160 mg/day) as a monotherapy either on awakening or at bedtime. Blood pressure was measured every 20 min during the day and every 30 min at night for 48 consecutive hours before and after 3 months of treatment. Physical activity was simultaneously monitored every minute by wrist actigraphy to accurately calculate the diurnal and nocturnal means of blood pressure on a per subject basis.
RESULTS: The significant blood pressure reduction after 3 months of valsartan (P<0.001) was similar for both treatment times (13.1 and 8.5 mmHg reduction in the 24-h mean of systolic and diastolic blood pressure with morning administration; 14.7 and 10.3 mmHg with bedtime administration; P>0.126 for treatment-time effect). The diurnal: nocturnal ratio of blood pressure was significantly increased only when valsartan was administered before bedtime, which resulted in 75% of the patients in this group reverting to dippers, a significant increase in the percentage of patients with controlled blood pressure over 24 h, and a reduction in urinary albumin excretion.
CONCLUSIONS: In non-dipper hypertensive patients, dosing time with valsartan should be chosen at bedtime, for improved efficacy during the nocturnal resting hours, as well as the potential associated reduction in cardiovascular risk.
| Errataetall: |
CommentIn: J Hypertens. 2005 Oct;23(10):1799-801. - PMID 16148601 |
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| Medienart: |
Artikel |
| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
|---|---|
| Enthalten in: |
Journal of hypertension - 23(2005), 10 vom: 21. Okt., Seite 1913-22 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hermida, Ramón C [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 21.12.2005 Date Revised 23.08.2019 published: Print CommentIn: J Hypertens. 2005 Oct;23(10):1799-801. - PMID 16148601 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM157645371 |
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| 035 | |a (NLM)16148616 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hermida, Ramón C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Treatment of non-dipper hypertension with bedtime administration of valsartan |
| 264 | 1 | |c 2005 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 21.12.2005 | ||
| 500 | |a Date Revised 23.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: J Hypertens. 2005 Oct;23(10):1799-801. - PMID 16148601 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Previous results have indicated that valsartan administration at bedtime, as opposed to upon wakening, may improve the diurnal: nocturnal ratio of blood pressure without loss in 24-h coverage and efficacy | ||
| 520 | |a OBJECTIVES: To investigate the administration time-dependent antihypertensive efficacy of valsartan in non-dipper patients | ||
| 520 | |a METHODS: We studied 148 non-dipper patients with grade 1-2 essential hypertension, aged 53.0+/-12.6 years, who were randomly assigned to receive valsartan (160 mg/day) as a monotherapy either on awakening or at bedtime. Blood pressure was measured every 20 min during the day and every 30 min at night for 48 consecutive hours before and after 3 months of treatment. Physical activity was simultaneously monitored every minute by wrist actigraphy to accurately calculate the diurnal and nocturnal means of blood pressure on a per subject basis | ||
| 520 | |a RESULTS: The significant blood pressure reduction after 3 months of valsartan (P<0.001) was similar for both treatment times (13.1 and 8.5 mmHg reduction in the 24-h mean of systolic and diastolic blood pressure with morning administration; 14.7 and 10.3 mmHg with bedtime administration; P>0.126 for treatment-time effect). The diurnal: nocturnal ratio of blood pressure was significantly increased only when valsartan was administered before bedtime, which resulted in 75% of the patients in this group reverting to dippers, a significant increase in the percentage of patients with controlled blood pressure over 24 h, and a reduction in urinary albumin excretion | ||
| 520 | |a CONCLUSIONS: In non-dipper hypertensive patients, dosing time with valsartan should be chosen at bedtime, for improved efficacy during the nocturnal resting hours, as well as the potential associated reduction in cardiovascular risk | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Angiotensin II Type 1 Receptor Blockers |2 NLM | |
| 650 | 7 | |a Antihypertensive Agents |2 NLM | |
| 650 | 7 | |a Tetrazoles |2 NLM | |
| 650 | 7 | |a Valsartan |2 NLM | |
| 650 | 7 | |a 80M03YXJ7I |2 NLM | |
| 650 | 7 | |a Valine |2 NLM | |
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| 700 | 1 | |a Calvo, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Ayala, Diana E |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández, José R |e verfasserin |4 aut | |
| 700 | 1 | |a Covelo, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Mojón, Artemio |e verfasserin |4 aut | |
| 700 | 1 | |a López, José E |e verfasserin |4 aut | |
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