Individualized adjuvant chemotherapy guided by chemosensitivity test sequential to extended surgery for advanced gastric cancer
BACKGROUND AND OBJECTIVES: Various adjuvant chemotherapy regimens have been proposed for patients with advanced gastric cancer; however, the majority of these trials failed to show a clear survival benefit over surgery alone. In this study, the feasibility and efficacy of a strategy of extended surgery combined with individualized adjuvant chemotherapy for advanced gastric cancer with serosal invasion and nodal involvement was examined.
PATIENTS AND METHODS: Sixty-four patients with advanced gastric cancer underwent gastrectomy with extended lymph node dissection. After surgery, a chemosensitivity test by MTT assay, using highly purified tumor cells, was performed, and the patients received individualized adjuvant chemotherapy on the basis of the results of this chemosensitivity test.
RESULTS: Overall survival in the chemosensitivity-guided chemotherapy (CSC) group was significantly better than the standard chemotherapy (SC) and the no-chemotherapy (NC) group (p<0.05). In patients with stage IV disease, the 5-year survival rate was 38.1% in the CSC group and 0% in the SC + NC group, respectively, with a significant difference being observed in the two survival curves (p<0.01). In patients with paraaortic node involvement, survival in the CSC group was significantly better than that in the SC + NC group (p<0.01). On the other hand, in patients without paraaortic node involvement, no survival difference was observed between the two groups.
CONCLUSION: The strategy of extended surgery combined with individualized adjuvant chemotherapy offers a favorable survival outcome for advanced gastric cancer patients with serosal invasion and nodal involvement.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Anticancer research - 25(2005), 5 vom: 15. Sept., Seite 3453-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Iwahashi, Makoto [VerfasserIn] |
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| Themen: |
50SG953SK6 |
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| Anmerkungen: |
Date Completed 13.10.2005 Date Revised 24.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM157201147 |
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| 100 | 1 | |a Iwahashi, Makoto |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Individualized adjuvant chemotherapy guided by chemosensitivity test sequential to extended surgery for advanced gastric cancer |
| 264 | 1 | |c 2005 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 24.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND OBJECTIVES: Various adjuvant chemotherapy regimens have been proposed for patients with advanced gastric cancer; however, the majority of these trials failed to show a clear survival benefit over surgery alone. In this study, the feasibility and efficacy of a strategy of extended surgery combined with individualized adjuvant chemotherapy for advanced gastric cancer with serosal invasion and nodal involvement was examined | ||
| 520 | |a PATIENTS AND METHODS: Sixty-four patients with advanced gastric cancer underwent gastrectomy with extended lymph node dissection. After surgery, a chemosensitivity test by MTT assay, using highly purified tumor cells, was performed, and the patients received individualized adjuvant chemotherapy on the basis of the results of this chemosensitivity test | ||
| 520 | |a RESULTS: Overall survival in the chemosensitivity-guided chemotherapy (CSC) group was significantly better than the standard chemotherapy (SC) and the no-chemotherapy (NC) group (p<0.05). In patients with stage IV disease, the 5-year survival rate was 38.1% in the CSC group and 0% in the SC + NC group, respectively, with a significant difference being observed in the two survival curves (p<0.01). In patients with paraaortic node involvement, survival in the CSC group was significantly better than that in the SC + NC group (p<0.01). On the other hand, in patients without paraaortic node involvement, no survival difference was observed between the two groups | ||
| 520 | |a CONCLUSION: The strategy of extended surgery combined with individualized adjuvant chemotherapy offers a favorable survival outcome for advanced gastric cancer patients with serosal invasion and nodal involvement | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Thiazoles |2 NLM | |
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| 650 | 7 | |a 50SG953SK6 |2 NLM | |
| 650 | 7 | |a Doxorubicin |2 NLM | |
| 650 | 7 | |a 80168379AG |2 NLM | |
| 650 | 7 | |a thiazolyl blue |2 NLM | |
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| 650 | 7 | |a U3P01618RT |2 NLM | |
| 700 | 1 | |a Nakamori, Mikihito |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Noguchi, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakatani, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ojima, Toshiyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Ishida, Koichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Naka, Teiji |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaue, Hiroki |e verfasserin |4 aut | |
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