Cost-effectiveness analysis of rituximab combined with chop for treatment of diffuse large B-cell lymphoma
PURPOSE: To estimate the cost-effectiveness from a French payer perspective of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) alone compared with CHOP plus rituximab (R-CHOP) for treatment of patients with diffuse large B-cell lymphoma.
METHODS: Mean patient survival, days of hospitalization, and chemotherapy costs during treatment were estimated from a Phase III trial in France, Belgium, and Switzerland. Survival during the trial was estimated using the Kaplan-Meier method; survival beyond the trial period was projected based on mortality rates from the Scottish and Newcastle Lymphoma Group database. French diagnosis-related group (DRG) payment schedules were applied to trial data to estimate cost of adverse events and drug administration. We estimated survival and cost-effectiveness [the incremental cost per quality-adjusted life-year (QALY) gained] from 4 years (median clinical trial follow-up period) to 15 years, discounted at a fixed annual rate of 3%. We used published patient preferences. We converted currency to euros, based on 2003 exchange rates.
RESULTS: R-CHOP resulted in a 20.6% relative increase in complete response rate (absolute increase from 63% to 76%), and a 31% decrease in risk of death at 4 years (95% CI 8-49%). Over a 15-year time horizon, mean overall survival (OS) duration was estimated to be 6.90 years for R-CHOP and 5.74 years for CHOP, a mean increase in OS of 1.16 years (or 1.07 QALYs). Total direct medical costs were 13,170 euro higher with R-CHOP, with an incremental cost-effectiveness ratio of 12,259 euro per QALY gained.
CONCLUSION: R-CHOP significantly increases mean OS up to 4 years compared with CHOP, and its cost-effectiveness ratio compares favorably with other oncology treatments in widespread use.
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2005 |
---|---|
Erschienen: |
2005 |
Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
---|---|
Enthalten in: |
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research - 8(2005), 4 vom: 15. Juli, Seite 462-70 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Best, Jennie H [VerfasserIn] |
---|
Anmerkungen: |
Date Completed 20.09.2005 Date Revised 20.04.2022 published: Print Citation Status MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM157104079 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM157104079 | ||
003 | DE-627 | ||
005 | 20231223075511.0 | ||
007 | tu | ||
008 | 231223s2005 xx ||||| 00| ||eng c | ||
028 | 5 | 2 | |a pubmed24n0524.xml |
035 | |a (DE-627)NLM157104079 | ||
035 | |a (NLM)16091023 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Best, Jennie H |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cost-effectiveness analysis of rituximab combined with chop for treatment of diffuse large B-cell lymphoma |
264 | 1 | |c 2005 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Completed 20.09.2005 | ||
500 | |a Date Revised 20.04.2022 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a PURPOSE: To estimate the cost-effectiveness from a French payer perspective of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) alone compared with CHOP plus rituximab (R-CHOP) for treatment of patients with diffuse large B-cell lymphoma | ||
520 | |a METHODS: Mean patient survival, days of hospitalization, and chemotherapy costs during treatment were estimated from a Phase III trial in France, Belgium, and Switzerland. Survival during the trial was estimated using the Kaplan-Meier method; survival beyond the trial period was projected based on mortality rates from the Scottish and Newcastle Lymphoma Group database. French diagnosis-related group (DRG) payment schedules were applied to trial data to estimate cost of adverse events and drug administration. We estimated survival and cost-effectiveness [the incremental cost per quality-adjusted life-year (QALY) gained] from 4 years (median clinical trial follow-up period) to 15 years, discounted at a fixed annual rate of 3%. We used published patient preferences. We converted currency to euros, based on 2003 exchange rates | ||
520 | |a RESULTS: R-CHOP resulted in a 20.6% relative increase in complete response rate (absolute increase from 63% to 76%), and a 31% decrease in risk of death at 4 years (95% CI 8-49%). Over a 15-year time horizon, mean overall survival (OS) duration was estimated to be 6.90 years for R-CHOP and 5.74 years for CHOP, a mean increase in OS of 1.16 years (or 1.07 QALYs). Total direct medical costs were 13,170 euro higher with R-CHOP, with an incremental cost-effectiveness ratio of 12,259 euro per QALY gained | ||
520 | |a CONCLUSION: R-CHOP significantly increases mean OS up to 4 years compared with CHOP, and its cost-effectiveness ratio compares favorably with other oncology treatments in widespread use | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 7 | |a Antibodies, Monoclonal |2 NLM | |
650 | 7 | |a Antibodies, Monoclonal, Murine-Derived |2 NLM | |
650 | 7 | |a Rituximab |2 NLM | |
650 | 7 | |a 4F4X42SYQ6 |2 NLM | |
650 | 7 | |a Vincristine |2 NLM | |
650 | 7 | |a 5J49Q6B70F |2 NLM | |
650 | 7 | |a Doxorubicin |2 NLM | |
650 | 7 | |a 80168379AG |2 NLM | |
650 | 7 | |a Cyclophosphamide |2 NLM | |
650 | 7 | |a 8N3DW7272P |2 NLM | |
650 | 7 | |a Prednisone |2 NLM | |
650 | 7 | |a VB0R961HZT |2 NLM | |
700 | 1 | |a Hornberger, John |e verfasserin |4 aut | |
700 | 1 | |a Proctor, Stephen J |e verfasserin |4 aut | |
700 | 1 | |a Omnes, Louis F |e verfasserin |4 aut | |
700 | 1 | |a Jost, Fred |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research |d 1998 |g 8(2005), 4 vom: 15. Juli, Seite 462-70 |w (DE-627)NLM115934545 |x 1524-4733 |7 nnns |
773 | 1 | 8 | |g volume:8 |g year:2005 |g number:4 |g day:15 |g month:07 |g pages:462-70 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 8 |j 2005 |e 4 |b 15 |c 07 |h 462-70 |