Serotonin syndrome as a result of concomitant use of paroxetine and sumatriptan
A 65-year-old woman was referred with confusion, strange behaviour, sinus tachycardia, hypertension and hyperthermia. She had been taking sumatriptan and paroxetine and recovered completely after discontinuation of these agents. The diagnosis was 'serotonin syndrome', a result of overstimulation of 5-HT(1A) receptors in the raphe nuclei of the brainstem. It is a complication of the use of serotonergic agents and is associated with the rapid onset of mental, autonomic and neurological symptoms. Treatment consists of discontinuation of the suspected medication and, in severe cases, providing symptomatic relief. Given the frequent prescription of (combinations of) serotonergic agents, one should be aware of this complication.
| Errataetall: |
CommentIn: Ned Tijdschr Geneeskd. 2005 Jul 16;149(29):1654; author reply 1654. - PMID 16078777 |
|---|---|
| Medienart: |
Artikel |
| Erscheinungsjahr: |
2005 |
|---|---|
| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:149 |
|---|---|
| Enthalten in: |
Nederlands tijdschrift voor geneeskunde - 149(2005), 16 vom: 16. Apr., Seite 888-90 |
| Sprache: |
Niederländisch |
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| Weiterer Titel: |
Het serotoninesyndroom bij gelijktijdig gebruik van paroxetine en sumatriptan |
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| Beteiligte Personen: |
Hendrix, Y [VerfasserIn] |
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| Themen: |
333DO1RDJY |
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| Anmerkungen: |
Date Completed 09.06.2005 Date Revised 07.12.2022 published: Print CommentIn: Ned Tijdschr Geneeskd. 2005 Jul 16;149(29):1654; author reply 1654. - PMID 16078777 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM155163779 |
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| 245 | 1 | 0 | |a Serotonin syndrome as a result of concomitant use of paroxetine and sumatriptan |
| 246 | 3 | 3 | |a Het serotoninesyndroom bij gelijktijdig gebruik van paroxetine en sumatriptan |
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| 500 | |a CommentIn: Ned Tijdschr Geneeskd. 2005 Jul 16;149(29):1654; author reply 1654. - PMID 16078777 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A 65-year-old woman was referred with confusion, strange behaviour, sinus tachycardia, hypertension and hyperthermia. She had been taking sumatriptan and paroxetine and recovered completely after discontinuation of these agents. The diagnosis was 'serotonin syndrome', a result of overstimulation of 5-HT(1A) receptors in the raphe nuclei of the brainstem. It is a complication of the use of serotonergic agents and is associated with the rapid onset of mental, autonomic and neurological symptoms. Treatment consists of discontinuation of the suspected medication and, in severe cases, providing symptomatic relief. Given the frequent prescription of (combinations of) serotonergic agents, one should be aware of this complication | ||
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| 650 | 4 | |a English Abstract | |
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