Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease
A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
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| Enthalten in: |
American journal of hematology - 78(2005), 4 vom: 01. Apr., Seite 306-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bolaños-Meade, Javier [VerfasserIn] |
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| Themen: |
4QWG6N8QKH |
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| Anmerkungen: |
Date Completed 24.05.2005 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM154477931 |
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| 100 | 1 | |a Bolaños-Meade, Javier |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease |
| 264 | 1 | |c 2005 | |
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| 500 | |a Date Completed 24.05.2005 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Enzyme Inhibitors |2 NLM | |
| 650 | 7 | |a Immunosuppressive Agents |2 NLM | |
| 650 | 7 | |a Hydroxychloroquine |2 NLM | |
| 650 | 7 | |a 4QWG6N8QKH |2 NLM | |
| 700 | 1 | |a Zhou, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Hoke, Ahmet |e verfasserin |4 aut | |
| 700 | 1 | |a Corse, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Vogelsang, Georgia |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Kathryn R |e verfasserin |4 aut | |
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