Intra uterine insemination with processed sperm for HIV serodiscordant couples in whom the man is HIV positive
The desire to have children is more and more common in HIV serodiscordant couples. The Academic Medical Centre Amsterdam has developed a new treatment protocol for couples in whom the man is HIV positive. Semen is processed to obtain HIV-1 free spermatozoa. These spermatozoa are used for IUI treatment. Thus far, 20 serodiscordant couples underwent 76 IUI cycles. An insemination was performed in 50 cycles (66%). The insemination was cancelled in 26 cycles, because of too many follicles (risk for multiple pregnancy), weekend (no possibilities for virological testing), not enough spermatazoa after preparation, a positive HIV-1 RNA test and other reasons. 10 out of 20 women became pregnant (50%), 8 women were on-going pregnant. The clinical and ongoing pregnancy rate per started cycle was 13% and 11% respectively. 7 babies have thus far been born and none of the mothers or babies seroconverted within this study period. Larger numbers of patients are necessary to support the safety of this program.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:149 |
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| Enthalten in: |
Nederlands tijdschrift voor geneeskunde - 149(2005), 8 vom: 19. Feb., Seite 423-4 |
| Sprache: |
Niederländisch |
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| Weiterer Titel: |
Intra-uteriene inseminatie met bewerkt sperma bij HIV-serodiscordante paren met een HIV-positieve man |
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| Beteiligte Personen: |
van Leeuwen, E [VerfasserIn] |
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| Themen: |
English Abstract |
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| Anmerkungen: |
Date Completed 08.04.2005 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM154060666 |
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| 100 | 1 | |a van Leeuwen, E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Intra uterine insemination with processed sperm for HIV serodiscordant couples in whom the man is HIV positive |
| 246 | 3 | 3 | |a Intra-uteriene inseminatie met bewerkt sperma bij HIV-serodiscordante paren met een HIV-positieve man |
| 264 | 1 | |c 2005 | |
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| 500 | |a Date Completed 08.04.2005 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The desire to have children is more and more common in HIV serodiscordant couples. The Academic Medical Centre Amsterdam has developed a new treatment protocol for couples in whom the man is HIV positive. Semen is processed to obtain HIV-1 free spermatozoa. These spermatozoa are used for IUI treatment. Thus far, 20 serodiscordant couples underwent 76 IUI cycles. An insemination was performed in 50 cycles (66%). The insemination was cancelled in 26 cycles, because of too many follicles (risk for multiple pregnancy), weekend (no possibilities for virological testing), not enough spermatazoa after preparation, a positive HIV-1 RNA test and other reasons. 10 out of 20 women became pregnant (50%), 8 women were on-going pregnant. The clinical and ongoing pregnancy rate per started cycle was 13% and 11% respectively. 7 babies have thus far been born and none of the mothers or babies seroconverted within this study period. Larger numbers of patients are necessary to support the safety of this program | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a de Vries, J W A |e verfasserin |4 aut | |
| 700 | 1 | |a Jurriaans, S |e verfasserin |4 aut | |
| 700 | 1 | |a Verhoeve, H R |e verfasserin |4 aut | |
| 700 | 1 | |a Prins, J M |e verfasserin |4 aut | |
| 700 | 1 | |a Repping, S |e verfasserin |4 aut | |
| 700 | 1 | |a van der Veen, F |e verfasserin |4 aut | |
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