Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Nature medicine - 11(2005), 1 vom: 18. Jan., Seite 32-4 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yamada, Kazuhiko [VerfasserIn] |
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| Themen: |
13168-24-6 |
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| Anmerkungen: |
Date Completed 24.03.2005 Date Revised 21.11.2013 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM152818049 |
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| 100 | 1 | |a Yamada, Kazuhiko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
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| 700 | 1 | |a Yazawa, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Iwanaga, Takehiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hisashi, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nuhn, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a O'Malley, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Nobori, Shuji |e verfasserin |4 aut | |
| 700 | 1 | |a Vagefi, Parsia A |e verfasserin |4 aut | |
| 700 | 1 | |a Patience, Clive |e verfasserin |4 aut | |
| 700 | 1 | |a Fishman, Jay |e verfasserin |4 aut | |
| 700 | 1 | |a Cooper, David K C |e verfasserin |4 aut | |
| 700 | 1 | |a Hawley, Robert J |e verfasserin |4 aut | |
| 700 | 1 | |a Greenstein, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Schuurman, Henk-Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Awwad, Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Sykes, Megan |e verfasserin |4 aut | |
| 700 | 1 | |a Sachs, David H |e verfasserin |4 aut | |
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