Interferon alpha production in the serum of very young infants after viral infections
UNLABELLED: IFN-alpha detection is useful in some clinical circumstances, but its use has never been validated in young infants with viral infections.
OBJECTIVE: The authors wanted to determine it there was any difference in the assessment of IFN-alpha production between infants under or over six months of age.
PATIENTS AND METHOD: A series of 233 children with identified common viral infections who had been assessed for IFN-alpha production was retrospectively analyzed. The viral infections were enteroviral meningitis (n =103), respiratory syncytial virus infections (n =60), and rotavirus gastroenteritis (n =70). Data collected from the group of infants under six months of age (n =105) was compared to that of the older children (n =128). Qualitative and quantitative values of interferon-alpha were determined for each group.
RESULTS: Interferon-alpha was detected in very young infants (81.9% of cases) as often as in the older age group (80.3% of cases), for any of the three viral infections (P =0.3-0.63). The mean level of interferon-alpha production detected was not lower in the youngest group, and even higher in the group under six months of age with enteroviral meningitis.
CONCLUSION: Interferon-alpha detection in very young infants is efficient and may be useful to differentiate between viral and bacterial infection particularly when the etiological diagnosis appears uncertain.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2004 |
|---|---|
| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Medecine et maladies infectieuses - 34(2004), 12 vom: 15. Dez., Seite 561-5 |
| Sprache: |
Französisch |
|---|
| Weiterer Titel: |
Production d'interféron alpha dans le sérum des très jeunes nourrissons lors d'infections virales |
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| Beteiligte Personen: |
Dubos, F [VerfasserIn] |
|---|
| Themen: |
Comparative Study |
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| Anmerkungen: |
Date Completed 16.05.2005 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
|
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| PPN (Katalog-ID): |
NLM152672362 |
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| 100 | 1 | |a Dubos, F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Interferon alpha production in the serum of very young infants after viral infections |
| 246 | 3 | 3 | |a Production d'interféron alpha dans le sérum des très jeunes nourrissons lors d'infections virales |
| 264 | 1 | |c 2004 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 16.05.2005 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a UNLABELLED: IFN-alpha detection is useful in some clinical circumstances, but its use has never been validated in young infants with viral infections | ||
| 520 | |a OBJECTIVE: The authors wanted to determine it there was any difference in the assessment of IFN-alpha production between infants under or over six months of age | ||
| 520 | |a PATIENTS AND METHOD: A series of 233 children with identified common viral infections who had been assessed for IFN-alpha production was retrospectively analyzed. The viral infections were enteroviral meningitis (n =103), respiratory syncytial virus infections (n =60), and rotavirus gastroenteritis (n =70). Data collected from the group of infants under six months of age (n =105) was compared to that of the older children (n =128). Qualitative and quantitative values of interferon-alpha were determined for each group | ||
| 520 | |a RESULTS: Interferon-alpha was detected in very young infants (81.9% of cases) as often as in the older age group (80.3% of cases), for any of the three viral infections (P =0.3-0.63). The mean level of interferon-alpha production detected was not lower in the youngest group, and even higher in the group under six months of age with enteroviral meningitis | ||
| 520 | |a CONCLUSION: Interferon-alpha detection in very young infants is efficient and may be useful to differentiate between viral and bacterial infection particularly when the etiological diagnosis appears uncertain | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Interferon-alpha |2 NLM | |
| 700 | 1 | |a Lorrot, M |e verfasserin |4 aut | |
| 700 | 1 | |a Soulier, M |e verfasserin |4 aut | |
| 700 | 1 | |a Rozenberg, F |e verfasserin |4 aut | |
| 700 | 1 | |a Lebon, P |e verfasserin |4 aut | |
| 700 | 1 | |a Gendrel, D |e verfasserin |4 aut | |
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