Brain-derived neurotrophic factor in platelets and airflow limitation in asthma
Brain-derived neurotrophic factor (BDNF), a key mediator of neuronal plasticity, contributes to airway obstruction and hyperresponsiveness in a model of allergic asthma. BDNF is stored in human platelets and circulates in human plasma, but the significance of BDNF in this compartment is poorly understood. We investigated the relationship between platelet and plasma BDNF levels and pulmonary function in a cohort of 26 adult patients with recently diagnosed allergic asthma. BDNF levels in serum, platelets, and plasma were significantly increased in participants with asthma, as compared with 26 age- and sex-matched control subjects. In steroid-naive patients, but not in patients using inhaled corticosteroids, enhanced platelet BDNF levels correlated with parameters of airway obstruction and airway hyperresponsiveness to histamine. Experiments with activated peripheral blood mononuclear cells revealed that corticosteroids such as fluticasone effectively suppress BDNF secretion. In conclusion, we demonstrate that enhanced platelet BDNF is associated with airflow limitation and airway hyperresponsiveness in asthma. In addition, we provide evidence that corticosteroids suppress BDNF production by activated immune cells.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:171 |
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| Enthalten in: |
American journal of respiratory and critical care medicine - 171(2005), 2 vom: 15. Jan., Seite 115-20 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lommatzsch, Marek [VerfasserIn] |
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| Themen: |
Anti-Inflammatory Agents |
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| Anmerkungen: |
Date Completed 15.02.2005 Date Revised 15.11.2006 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM151860289 |
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| 100 | 1 | |a Lommatzsch, Marek |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Brain-derived neurotrophic factor in platelets and airflow limitation in asthma |
| 264 | 1 | |c 2005 | |
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| 500 | |a Date Completed 15.02.2005 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Brain-derived neurotrophic factor (BDNF), a key mediator of neuronal plasticity, contributes to airway obstruction and hyperresponsiveness in a model of allergic asthma. BDNF is stored in human platelets and circulates in human plasma, but the significance of BDNF in this compartment is poorly understood. We investigated the relationship between platelet and plasma BDNF levels and pulmonary function in a cohort of 26 adult patients with recently diagnosed allergic asthma. BDNF levels in serum, platelets, and plasma were significantly increased in participants with asthma, as compared with 26 age- and sex-matched control subjects. In steroid-naive patients, but not in patients using inhaled corticosteroids, enhanced platelet BDNF levels correlated with parameters of airway obstruction and airway hyperresponsiveness to histamine. Experiments with activated peripheral blood mononuclear cells revealed that corticosteroids such as fluticasone effectively suppress BDNF secretion. In conclusion, we demonstrate that enhanced platelet BDNF is associated with airflow limitation and airway hyperresponsiveness in asthma. In addition, we provide evidence that corticosteroids suppress BDNF production by activated immune cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Brain-Derived Neurotrophic Factor |2 NLM | |
| 650 | 7 | |a Glucocorticoids |2 NLM | |
| 700 | 1 | |a Schloetcke, Katharina |e verfasserin |4 aut | |
| 700 | 1 | |a Klotz, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Schuhbaeck, Katharina |e verfasserin |4 aut | |
| 700 | 1 | |a Zingler, Doerte |e verfasserin |4 aut | |
| 700 | 1 | |a Zingler, Christiana |e verfasserin |4 aut | |
| 700 | 1 | |a Schulte-Herbrüggen, Olaf |e verfasserin |4 aut | |
| 700 | 1 | |a Gill, Hartmut |e verfasserin |4 aut | |
| 700 | 1 | |a Schuff-Werner, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Virchow, Johann Christian |e verfasserin |4 aut | |
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