Comparison of the healing process in plated and non-plated fractures of the mandible in rats
We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n = 36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2004 |
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| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
The British journal of oral & maxillofacial surgery - 42(2004), 4 vom: 09. Aug., Seite 315-22 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rasubala, L [VerfasserIn] |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 20.09.2004 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM149116357 |
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| 100 | 1 | |a Rasubala, L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of the healing process in plated and non-plated fractures of the mandible in rats |
| 264 | 1 | |c 2004 | |
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| 500 | |a Date Completed 20.09.2004 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n = 36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Bmp2 protein, rat |2 NLM | |
| 650 | 7 | |a Bone Morphogenetic Protein 2 |2 NLM | |
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| 700 | 1 | |a Islam, A A S |e verfasserin |4 aut | |
| 700 | 1 | |a Nagata, K |e verfasserin |4 aut | |
| 700 | 1 | |a Iijima, T |e verfasserin |4 aut | |
| 700 | 1 | |a Ohishi, M |e verfasserin |4 aut | |
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