Piperazine-linked bisbenzamidines : a novel class of antileishmanial agents
A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC(50) value of 0.41 microM which is about sevenfold more potent than pentamidine.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2004 |
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| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
European journal of medicinal chemistry - 39(2004), 6 vom: 15. Juni, Seite 547-53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mayence, Annie [VerfasserIn] |
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| Themen: |
9007-49-2 |
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| Anmerkungen: |
Date Completed 14.02.2005 Date Revised 14.11.2007 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM148721567 |
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| 100 | 1 | |a Mayence, Annie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Piperazine-linked bisbenzamidines |b a novel class of antileishmanial agents |
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| 500 | |a Date Completed 14.02.2005 | ||
| 500 | |a Date Revised 14.11.2007 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC(50) value of 0.41 microM which is about sevenfold more potent than pentamidine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Antiprotozoal Agents |2 NLM | |
| 650 | 7 | |a Piperazines |2 NLM | |
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| 700 | 1 | |a Vanden Eynde, Jean Jacques |e verfasserin |4 aut | |
| 700 | 1 | |a LeCour, Louis |c Jr |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Larry A |e verfasserin |4 aut | |
| 700 | 1 | |a Tekwani, Babu L |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Tien L |e verfasserin |4 aut | |
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