Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice
The pathogenic mechanisms by which physical exercise influences atherosclerotic lesion formation remain poorly understood. Because vigorous physical training increases oxidative stress, this study tested the hypothesis that graduated and moderate physical exercise together with metabolic intervention (l-arginine and antioxidants) may contribute to increased vascular protection. Exercise training in mice was induced by graduated swimming. In hypercholesterolemic male mice on an atherogenic high-cholesterol diet, graduated and moderate exercise lowered plasma cholesterol and decreased atherosclerotic lesions compared with sedentary control mice. Antioxidants (1.0% vitamin E added to the chow and 0.05% vitamin C added to the drinking water) and l-arginine (6% in drinking water) supplementation to exercising hypercholesterolemic mice further and synergistically reduced atherosclerosis compared with untreated exercised mice. Arterial oxidation-specific epitopes and systemic oxidative stress were reduced by metabolic intervention. Graduated chronic exercise elicited an increase in production of nitric oxide through increased endothelial nitric oxide synthase expression and ameliorated scavenger activities. Thus, metabolic intervention with l-arginine and antioxidants together with graduated and moderate exercise training reduce atherosclerotic lesion formation.
| Errataetall: |
ErratumIn: Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18262 |
|---|---|
| Medienart: |
Artikel |
| Erscheinungsjahr: |
2004 |
|---|---|
| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:101 |
|---|---|
| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 101(2004), 23 vom: 08. Juni, Seite 8797-802 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Napoli, Claudio [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 17.08.2004 Date Revised 13.11.2018 published: Print-Electronic ErratumIn: Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18262 Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM148588557 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM148588557 | ||
| 003 | DE-627 | ||
| 005 | 20231223045914.0 | ||
| 007 | tu | ||
| 008 | 231223s2004 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0495.xml |
| 035 | |a (DE-627)NLM148588557 | ||
| 035 | |a (NLM)15169957 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Napoli, Claudio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice |
| 264 | 1 | |c 2004 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 17.08.2004 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18262 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The pathogenic mechanisms by which physical exercise influences atherosclerotic lesion formation remain poorly understood. Because vigorous physical training increases oxidative stress, this study tested the hypothesis that graduated and moderate physical exercise together with metabolic intervention (l-arginine and antioxidants) may contribute to increased vascular protection. Exercise training in mice was induced by graduated swimming. In hypercholesterolemic male mice on an atherogenic high-cholesterol diet, graduated and moderate exercise lowered plasma cholesterol and decreased atherosclerotic lesions compared with sedentary control mice. Antioxidants (1.0% vitamin E added to the chow and 0.05% vitamin C added to the drinking water) and l-arginine (6% in drinking water) supplementation to exercising hypercholesterolemic mice further and synergistically reduced atherosclerosis compared with untreated exercised mice. Arterial oxidation-specific epitopes and systemic oxidative stress were reduced by metabolic intervention. Graduated chronic exercise elicited an increase in production of nitric oxide through increased endothelial nitric oxide synthase expression and ameliorated scavenger activities. Thus, metabolic intervention with l-arginine and antioxidants together with graduated and moderate exercise training reduce atherosclerotic lesion formation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Receptors, LDL |2 NLM | |
| 650 | 7 | |a Vitamin E |2 NLM | |
| 650 | 7 | |a 1406-18-4 |2 NLM | |
| 650 | 7 | |a Arginine |2 NLM | |
| 650 | 7 | |a 94ZLA3W45F |2 NLM | |
| 650 | 7 | |a Nitric Oxide Synthase |2 NLM | |
| 650 | 7 | |a EC 1.14.13.39 |2 NLM | |
| 650 | 7 | |a Nitric Oxide Synthase Type II |2 NLM | |
| 650 | 7 | |a EC 1.14.13.39 |2 NLM | |
| 650 | 7 | |a Nitric Oxide Synthase Type III |2 NLM | |
| 650 | 7 | |a EC 1.14.13.39 |2 NLM | |
| 650 | 7 | |a Nos2 protein, mouse |2 NLM | |
| 650 | 7 | |a EC 1.14.13.39 |2 NLM | |
| 650 | 7 | |a Nos3 protein, mouse |2 NLM | |
| 650 | 7 | |a EC 1.14.13.39 |2 NLM | |
| 650 | 7 | |a Ascorbic Acid |2 NLM | |
| 650 | 7 | |a PQ6CK8PD0R |2 NLM | |
| 700 | 1 | |a Williams-Ignarro, Sharon |e verfasserin |4 aut | |
| 700 | 1 | |a De Nigris, Filomena |e verfasserin |4 aut | |
| 700 | 1 | |a Lerman, Lilach O |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Loredana |e verfasserin |4 aut | |
| 700 | 1 | |a Guarino, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Mansueto, Gelsomina |e verfasserin |4 aut | |
| 700 | 1 | |a Di Tuoro, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Pignalosa, Orlando |e verfasserin |4 aut | |
| 700 | 1 | |a De Rosa, Gaetano |e verfasserin |4 aut | |
| 700 | 1 | |a Sica, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Ignarro, Louis J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Proceedings of the National Academy of Sciences of the United States of America |d 1915 |g 101(2004), 23 vom: 08. Juni, Seite 8797-802 |w (DE-627)NLM000008982 |x 1091-6490 |7 nnns |
| 773 | 1 | 8 | |g volume:101 |g year:2004 |g number:23 |g day:08 |g month:06 |g pages:8797-802 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 101 |j 2004 |e 23 |b 08 |c 06 |h 8797-802 | ||