Evidences for the formation of bisbenzamidine-heme complexes in cell-free systems
Infrared and colorimetry data suggest that bisbenzamidines connected by various rigid or flexible linkers are able to interact with heme in cell-free systems. At pH 5.0 the inhibition of formation of beta-hematin could be ascertained by infrared spectroscopy whereas at pH 7.0 the interaction yielded insoluble complexes for which a sandwich-type structure of stoichiometry 2:1, heme-drug, is tentatively proposed.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2004 |
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| Erschienen: |
2004 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 14(2004), 7 vom: 05. Apr., Seite 1625-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mayence, Annie [VerfasserIn] |
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| Themen: |
42VZT0U6YR |
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| Anmerkungen: |
Date Completed 26.10.2004 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM147252113 |
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| 100 | 1 | |a Mayence, Annie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evidences for the formation of bisbenzamidine-heme complexes in cell-free systems |
| 264 | 1 | |c 2004 | |
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| 500 | |a Date Completed 26.10.2004 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Infrared and colorimetry data suggest that bisbenzamidines connected by various rigid or flexible linkers are able to interact with heme in cell-free systems. At pH 5.0 the inhibition of formation of beta-hematin could be ascertained by infrared spectroscopy whereas at pH 7.0 the interaction yielded insoluble complexes for which a sandwich-type structure of stoichiometry 2:1, heme-drug, is tentatively proposed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Antimalarials |2 NLM | |
| 650 | 7 | |a Benzamidines |2 NLM | |
| 650 | 7 | |a Heme |2 NLM | |
| 650 | 7 | |a 42VZT0U6YR |2 NLM | |
| 700 | 1 | |a Vanden Eynde, Jean Jacques |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Tien L |e verfasserin |4 aut | |
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