Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas

Selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR), and selenoprotein P (SePP) contain molecular selenium in form of selenocysteines within their active center. They are involved in the defense of reactive oxygen species, which otherwise may cause DNA damage and alterations of protein function. Selenium intake has been linked to colon carcinogenesis in epidemiological and interventional studies. In a double-blinded, placebo-controlled trial, we demonstrate that carriers of colon adenomas present with low basal serum levels of selenium and plasma glutathione peroxidase (pGPx) activity before treatment, but both parameters can be normalized by interventional selenium supplementation. GPx activity in colon mucosa was enhanced in the verum group, albeit this had only borderline significance. No change of activity was observed for mucosal TrxR activity on selenium supplementation. In summary, our results confirm the existence of low selenium levels in patients prone to colon adenomas and show that by selenium supplementation this can be normalized. If prospective trials confirm that selenium supplementation reduces colon cancer incidence rates, it may be concluded that selenium supplementation should be recommended for patients at risk.

Medienart:

Artikel

Erscheinungsjahr:

2003

Erschienen:

2003

Enthalten in:

Zur Gesamtaufnahme - volume:46

Enthalten in:

Nutrition and cancer - 46(2003), 2 vom: 15., Seite 125-30

Sprache:

Englisch

Beteiligte Personen:

Al-Taie, Oliver H [VerfasserIn]
Seufert, Jochen [VerfasserIn]
Karvar, Serhan [VerfasserIn]
Adolph, Christian [VerfasserIn]
Mörk, Hubert [VerfasserIn]
Scheurlen, Michael [VerfasserIn]
Köhrle, Josef [VerfasserIn]
Jakob, Franz [VerfasserIn]

Themen:

Clinical Trial
EC 1.11.1.9
EC 1.8.1.9
Glutathione Peroxidase
H6241UJ22B
HIW548RQ3W
Journal Article
Placebos
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Selenium
Sodium Selenite
Thioredoxin-Disulfide Reductase

Anmerkungen:

Date Completed 25.05.2004

Date Revised 21.11.2013

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM144029014