Serial proton magnetic resonance spectroscopy of the brain in children undergoing cardiac surgery
We used proton magnetic resonance spectroscopy to study 11 children (age < 8 years) with congenital heart disease undergoing cardiopulmonary bypass to determine whether low (10 +/- 4; n = 6) vs high (20 +/- 4; n = 5) perfusate hematocrits during bypass resulted in changes in brain metabolites which correlate with neurologic injury. Long and short echo time single voxel magnetic resonance spectroscopy in occipital gray matter and neurologic assessment were performed preoperatively and 2 and 5 days postoperatively. We also determined whether prolonged periods at low flow rates during bypass affected spectroscopy variables. We found no significant differences in metabolite ratios between the low vs high hematocrit groups or the lower vs higher flow rate groups (repeated measures analysis of variance of observation ranks converted to normal scores). However, our study was limited by statistical power due to the small sample size, therefore no conclusions could be made. Additional studies involving a greater number of patients are necessary. In all 11 children, magnetic resonance spectroscopy detected a significant decrease in brain N-acetyl-aspartate, and increases in myoinositol and glutamate/glutamine after surgery (Quade test) demonstrating that magnetic resonance spectroscopy is sensitive in detecting subtle postoperative changes in brain metabolites.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2003 |
|---|---|
| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
|---|---|
| Enthalten in: |
Pediatric neurology - 29(2003), 2 vom: 27. Aug., Seite 99-110 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ashwal, Stephen [VerfasserIn] |
|---|
| Themen: |
0RH81L854J |
|---|
| Anmerkungen: |
Date Completed 09.01.2004 Date Revised 10.09.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM14303054X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM14303054X | ||
| 003 | DE-627 | ||
| 005 | 20231223025904.0 | ||
| 007 | tu | ||
| 008 | 231223s2003 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0477.xml |
| 035 | |a (DE-627)NLM14303054X | ||
| 035 | |a (NLM)14580652 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ashwal, Stephen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serial proton magnetic resonance spectroscopy of the brain in children undergoing cardiac surgery |
| 264 | 1 | |c 2003 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 09.01.2004 | ||
| 500 | |a Date Revised 10.09.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We used proton magnetic resonance spectroscopy to study 11 children (age < 8 years) with congenital heart disease undergoing cardiopulmonary bypass to determine whether low (10 +/- 4; n = 6) vs high (20 +/- 4; n = 5) perfusate hematocrits during bypass resulted in changes in brain metabolites which correlate with neurologic injury. Long and short echo time single voxel magnetic resonance spectroscopy in occipital gray matter and neurologic assessment were performed preoperatively and 2 and 5 days postoperatively. We also determined whether prolonged periods at low flow rates during bypass affected spectroscopy variables. We found no significant differences in metabolite ratios between the low vs high hematocrit groups or the lower vs higher flow rate groups (repeated measures analysis of variance of observation ranks converted to normal scores). However, our study was limited by statistical power due to the small sample size, therefore no conclusions could be made. Additional studies involving a greater number of patients are necessary. In all 11 children, magnetic resonance spectroscopy detected a significant decrease in brain N-acetyl-aspartate, and increases in myoinositol and glutamate/glutamine after surgery (Quade test) demonstrating that magnetic resonance spectroscopy is sensitive in detecting subtle postoperative changes in brain metabolites | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 7 | |a Glutamine |2 NLM | |
| 650 | 7 | |a 0RH81L854J |2 NLM | |
| 650 | 7 | |a Aspartic Acid |2 NLM | |
| 650 | 7 | |a 30KYC7MIAI |2 NLM | |
| 650 | 7 | |a Glutamic Acid |2 NLM | |
| 650 | 7 | |a 3KX376GY7L |2 NLM | |
| 650 | 7 | |a Inositol |2 NLM | |
| 650 | 7 | |a 4L6452S749 |2 NLM | |
| 650 | 7 | |a N-acetylaspartate |2 NLM | |
| 650 | 7 | |a 997-55-7 |2 NLM | |
| 700 | 1 | |a Holshouser, Barbara A |e verfasserin |4 aut | |
| 700 | 1 | |a del Rio, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Karen A |e verfasserin |4 aut | |
| 700 | 1 | |a Applegate, Richard L |e verfasserin |4 aut | |
| 700 | 1 | |a Bailey, Leonard L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric neurology |d 1993 |g 29(2003), 2 vom: 27. Aug., Seite 99-110 |w (DE-627)NLM012947210 |x 1873-5150 |7 nnns |
| 773 | 1 | 8 | |g volume:29 |g year:2003 |g number:2 |g day:27 |g month:08 |g pages:99-110 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 29 |j 2003 |e 2 |b 27 |c 08 |h 99-110 | ||