Combination therapy in rheumatoid arthritis
BACKGROUND: During the last decade patients with active rheumatoid arthritis have been offered early and aggressive drug therapy in order to decrease the damaging effect of inflammation on cartilage and bone. Combination of two or more disease-modifying antirheumatic drugs has been used more frequently to achieve better efficacy than with monotherapy without increasing drug side effects.
MATERIALS AND METHODS: We have studied available rheumatological literature to find the best documented drug combinations.
RESULTS: The combination of methotrexate, sulfasalazine and hydroxychloroquine seems to be a well documented alternative, and so is the combination of methotrexate and cyclosporine. Modern biologic drugs like etanercept, infliximab and anakinra work best in combination with methotrexate.
INTERPRETATION: The combination of two or more disease-modifying antirheumatic drugs can be a good alternative to monotherapy in the treatment of patients with active rheumatoid arthritis, either when monotherapy has failed or unacceptable side effects have occurred, or as a first choice in patients who need very early and aggressive therapy. Combination therapy should only be initiated by a rheumatologist, after informed consent. A safe clinical and chemical monitoring must be organized in cooperation with the patient and the primary physician.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2003 |
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| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:123 |
|---|---|
| Enthalten in: |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 123(2003), 11 vom: 29. Mai, Seite 1511-3 |
| Sprache: |
Norwegisch |
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| Weiterer Titel: |
Kombinasjonsterapi ved revmatoid artritt |
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| Beteiligte Personen: |
Johnsen, Villy [VerfasserIn] |
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| Themen: |
3XC8GUZ6CB |
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| Anmerkungen: |
Date Completed 06.11.2003 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM125849508 |
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| 245 | 1 | 0 | |a Combination therapy in rheumatoid arthritis |
| 246 | 3 | 3 | |a Kombinasjonsterapi ved revmatoid artritt |
| 264 | 1 | |c 2003 | |
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| 500 | |a Date Completed 06.11.2003 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: During the last decade patients with active rheumatoid arthritis have been offered early and aggressive drug therapy in order to decrease the damaging effect of inflammation on cartilage and bone. Combination of two or more disease-modifying antirheumatic drugs has been used more frequently to achieve better efficacy than with monotherapy without increasing drug side effects | ||
| 520 | |a MATERIALS AND METHODS: We have studied available rheumatological literature to find the best documented drug combinations | ||
| 520 | |a RESULTS: The combination of methotrexate, sulfasalazine and hydroxychloroquine seems to be a well documented alternative, and so is the combination of methotrexate and cyclosporine. Modern biologic drugs like etanercept, infliximab and anakinra work best in combination with methotrexate | ||
| 520 | |a INTERPRETATION: The combination of two or more disease-modifying antirheumatic drugs can be a good alternative to monotherapy in the treatment of patients with active rheumatoid arthritis, either when monotherapy has failed or unacceptable side effects have occurred, or as a first choice in patients who need very early and aggressive therapy. Combination therapy should only be initiated by a rheumatologist, after informed consent. A safe clinical and chemical monitoring must be organized in cooperation with the patient and the primary physician | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Adjuvants, Immunologic |2 NLM | |
| 650 | 7 | |a Antirheumatic Agents |2 NLM | |
| 650 | 7 | |a Sulfasalazine |2 NLM | |
| 650 | 7 | |a 3XC8GUZ6CB |2 NLM | |
| 650 | 7 | |a Hydroxychloroquine |2 NLM | |
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| 650 | 7 | |a Cyclosporine |2 NLM | |
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| 650 | 7 | |a Methotrexate |2 NLM | |
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| 700 | 1 | |a Førre, Øystein |e verfasserin |4 aut | |
| 700 | 1 | |a Haga, Hans-Jacob |e verfasserin |4 aut | |
| 700 | 1 | |a Kvien, Tore Kristian |e verfasserin |4 aut | |
| 700 | 1 | |a Mikkelsen, Knut |e verfasserin |4 aut | |
| 700 | 1 | |a Nordvåg, Bjørn-Yngvar |e verfasserin |4 aut | |
| 700 | 1 | |a Rødevand, Erik |e verfasserin |4 aut | |
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