Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe
BACKGROUND AND PURPOSE: The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients.
METHODS: We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls.
RESULTS: We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm.
CONCLUSIONS: Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2003 |
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| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Stroke - 34(2003), 5 vom: 02. Mai, Seite 1207-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hofer, Anne [VerfasserIn] |
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| Themen: |
9007-58-3 |
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| Anmerkungen: |
Date Completed 30.06.2003 Date Revised 22.11.2016 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM124618529 |
|---|
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| 245 | 1 | 0 | |a Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe |
| 264 | 1 | |c 2003 | |
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| 500 | |a Date Revised 22.11.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND PURPOSE: The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients | ||
| 520 | |a METHODS: We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls | ||
| 520 | |a RESULTS: We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm | ||
| 520 | |a CONCLUSIONS: Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 700 | 1 | |a Hermans, Marcella |e verfasserin |4 aut | |
| 700 | 1 | |a Kubassek, Nina |e verfasserin |4 aut | |
| 700 | 1 | |a Sitzer, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Funke, Harald |e verfasserin |4 aut | |
| 700 | 1 | |a Stögbauer, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Ivaskevicius, Vytautas |e verfasserin |4 aut | |
| 700 | 1 | |a Oldenburg, Johannes |e verfasserin |4 aut | |
| 700 | 1 | |a Burtscher, Johannes |e verfasserin |4 aut | |
| 700 | 1 | |a Knopp, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Schoch, Beate |e verfasserin |4 aut | |
| 700 | 1 | |a Wanke, Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Hübner, Felix |e verfasserin |4 aut | |
| 700 | 1 | |a Deinsberger, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Meyer, Bernhard |e verfasserin |4 aut | |
| 700 | 1 | |a Boecher-Schwarz, Hans |e verfasserin |4 aut | |
| 700 | 1 | |a Poewe, Werner |e verfasserin |4 aut | |
| 700 | 1 | |a Raabe, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Steinmetz, Helmuth |e verfasserin |4 aut | |
| 700 | 1 | |a Auburger, Georg |e verfasserin |4 aut | |
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