N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action
The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro: (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2003 |
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| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
Journal of medicinal chemistry - 46(2003), 8 vom: 10. Apr., Seite 1546-53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lagoja, Irene M [VerfasserIn] |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Date Completed 08.05.2003 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM124449042 |
|---|
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| 041 | |a eng | ||
| 100 | 1 | |a Lagoja, Irene M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action |
| 264 | 1 | |c 2003 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 08.05.2003 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro: (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Imidazoles |2 NLM | |
| 650 | 7 | |a Reverse Transcriptase Inhibitors |2 NLM | |
| 650 | 7 | |a HIV Reverse Transcriptase |2 NLM | |
| 650 | 7 | |a EC 2.7.7.49 |2 NLM | |
| 700 | 1 | |a Pannecouque, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Van Aerschot, Arthur |e verfasserin |4 aut | |
| 700 | 1 | |a Witvrouw, Myriam |e verfasserin |4 aut | |
| 700 | 1 | |a Debyser, Zeger |e verfasserin |4 aut | |
| 700 | 1 | |a Balzarini, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Herdewijn, Piet |e verfasserin |4 aut | |
| 700 | 1 | |a De Clercq, Erik |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of medicinal chemistry |d 1963 |g 46(2003), 8 vom: 10. Apr., Seite 1546-53 |w (DE-627)NLM000006602 |x 1520-4804 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2003 |g number:8 |g day:10 |g month:04 |g pages:1546-53 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2003 |e 8 |b 10 |c 04 |h 1546-53 | ||