Treatment of Bell's palsy with acyclovir and methylprednisolone
OBJECTIVE: An open therapeutic trial was conducted in patients with Bell's palsy. Results were compared with data in the literature.
MATERIALS AND METHODS: Between 1997 and 2000, 76 patients with Bell's palsy were treated with intravenous methylprednisolone (2 mg/kg/day) and acyclovir (5-10 mg/kg/8 hours) for 7 days. Treatment was initiated in all patients before the 14th day of illness. Severity of the palsy was scored on the first day of treatment and again one year later using the House and Brackman scale.
RESULTS: Grade II or III palsy were observed in 38% of the patients at initial presentation, grades IV to VI in 62%. After treatment, 92% of the patients had reverted to grades I and II (good outcome) and only 8% had sequelae at 1-year follow-up. All patients with initial grade I or II recovered completely. For patients with grade IV, V, or VI complete recovery at 1 year was observed in 94, 86 and 50% respectively.
CONCLUSION: Data in the literature suggest that corticosteroids should improve recovery in Bell's plasy. In our study, adjunction of acyclovir did not demonstrate any clear improvement in the cure rate. Benefit could depend on early prescription.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2002 |
|---|---|
| Erschienen: |
2002 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
|---|---|
| Enthalten in: |
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris - 119(2002), 4 vom: 08. Sept., Seite 209-15 |
| Sprache: |
Französisch |
|---|
| Weiterer Titel: |
Traitement des paralysies faciales idiopathiques par méthylprednisolone et aciclovir |
|---|
| Beteiligte Personen: |
Lejeune, D [VerfasserIn] |
|---|
| Themen: |
Acyclovir |
|---|
| Anmerkungen: |
Date Completed 03.12.2002 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM121978532 |
|---|
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| 245 | 1 | 0 | |a Treatment of Bell's palsy with acyclovir and methylprednisolone |
| 246 | 3 | 3 | |a Traitement des paralysies faciales idiopathiques par méthylprednisolone et aciclovir |
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| 500 | |a Date Completed 03.12.2002 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: An open therapeutic trial was conducted in patients with Bell's palsy. Results were compared with data in the literature | ||
| 520 | |a MATERIALS AND METHODS: Between 1997 and 2000, 76 patients with Bell's palsy were treated with intravenous methylprednisolone (2 mg/kg/day) and acyclovir (5-10 mg/kg/8 hours) for 7 days. Treatment was initiated in all patients before the 14th day of illness. Severity of the palsy was scored on the first day of treatment and again one year later using the House and Brackman scale | ||
| 520 | |a RESULTS: Grade II or III palsy were observed in 38% of the patients at initial presentation, grades IV to VI in 62%. After treatment, 92% of the patients had reverted to grades I and II (good outcome) and only 8% had sequelae at 1-year follow-up. All patients with initial grade I or II recovered completely. For patients with grade IV, V, or VI complete recovery at 1 year was observed in 94, 86 and 50% respectively | ||
| 520 | |a CONCLUSION: Data in the literature suggest that corticosteroids should improve recovery in Bell's plasy. In our study, adjunction of acyclovir did not demonstrate any clear improvement in the cure rate. Benefit could depend on early prescription | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Acyclovir |2 NLM | |
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| 650 | 7 | |a Methylprednisolone |2 NLM | |
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| 700 | 1 | |a Bernat, I |e verfasserin |4 aut | |
| 700 | 1 | |a Vitte, E |e verfasserin |4 aut | |
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| 700 | 1 | |a Willer, J C |e verfasserin |4 aut | |
| 700 | 1 | |a Soudant, J |e verfasserin |4 aut | |
| 700 | 1 | |a Tankéré, F |e verfasserin |4 aut | |
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