Nonpsoriatic uses of calcipotriol
BACKGROUND: Calcipotriol is a synthetic vitamin D3 analog that binds to vitamin D receptors in epidermal cells. In vitro studies have shown that calcipotriol stimulates terminal cell differentiation and has antiproliferative effects. In vivo, calcipotriol has been shown to reduce the number of cycling epidermal cells. Calcipotriol also has less effect on calcium metabolism than calcitriol, which is the natural, bioactive, 1,25-dihydroxyvitamin D3.
OBJECTIVE: These properties make calcipotriol an ideal candidate for the topical treatment of hyperproliferative skin disorders. While it has been approved for topical use in psoriasis, its potential for use in other dermatological disorders has not yet been fully investigated.
CONCLUSION: This survey of the literature suggests that calcipotriol may show promise in the treatment of other conditions involving abnormal keratinization and hyperproliferation of epidermal cells. While some of these disorders are rare, and therefore difficult to study, further study into the nonpsoriatic uses of calcipotriol may be rewarding.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2002 |
|---|---|
| Erschienen: |
2002 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
|---|---|
| Enthalten in: |
Journal of cutaneous medicine and surgery - 6(2002), 5 vom: 27. Sept., Seite 442-8 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Gupta, Aditya K [VerfasserIn] |
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| Themen: |
143NQ3779B |
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| Anmerkungen: |
Date Completed 02.06.2003 Date Revised 06.11.2019 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM120563819 |
|---|
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| 100 | 1 | |a Gupta, Aditya K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nonpsoriatic uses of calcipotriol |
| 264 | 1 | |c 2002 | |
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| 500 | |a Date Completed 02.06.2003 | ||
| 500 | |a Date Revised 06.11.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Calcipotriol is a synthetic vitamin D3 analog that binds to vitamin D receptors in epidermal cells. In vitro studies have shown that calcipotriol stimulates terminal cell differentiation and has antiproliferative effects. In vivo, calcipotriol has been shown to reduce the number of cycling epidermal cells. Calcipotriol also has less effect on calcium metabolism than calcitriol, which is the natural, bioactive, 1,25-dihydroxyvitamin D3 | ||
| 520 | |a OBJECTIVE: These properties make calcipotriol an ideal candidate for the topical treatment of hyperproliferative skin disorders. While it has been approved for topical use in psoriasis, its potential for use in other dermatological disorders has not yet been fully investigated | ||
| 520 | |a CONCLUSION: This survey of the literature suggests that calcipotriol may show promise in the treatment of other conditions involving abnormal keratinization and hyperproliferation of epidermal cells. While some of these disorders are rare, and therefore difficult to study, further study into the nonpsoriatic uses of calcipotriol may be rewarding | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Dermatologic Agents |2 NLM | |
| 650 | 7 | |a calcipotriene |2 NLM | |
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| 700 | 1 | |a Browne, Melanie |e verfasserin |4 aut | |
| 700 | 1 | |a Bluhm, Robyn |e verfasserin |4 aut | |
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