Mimicry of annonaceous acetogenins : enantioselective synthesis of a (4R)-hydroxy analogue having potent antitumor activity
The (4R)-hydroxylated analogues of annonaceous acetogenin mimicking compound 2 were designed and synthesized structurally on the basis of the naturally occurring annonaceous acetogenin bullatacin, which was discovered as a typical member of the novel family of polyketides with potent cytotoxicity, antitumoral, and other biological activities. The preliminary screenings show that the IC(50) values of 2 were 1.6 x 10(-3) and 8 x 10(-2) microg/mL against HT-29 and HCT-8, respectively. A remarkable enhancement effect was observed by the activity comparison of 1c and its (4R)-hydroxylated analogue 2.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2002 |
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| Erschienen: |
2002 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
The Journal of organic chemistry - 67(2002), 10 vom: 17. Mai, Seite 3404-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jiang, Sheng [VerfasserIn] |
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| Anmerkungen: |
Date Completed 09.12.2002 Date Revised 10.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM118800159 |
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| 100 | 1 | |a Jiang, Sheng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mimicry of annonaceous acetogenins |b enantioselective synthesis of a (4R)-hydroxy analogue having potent antitumor activity |
| 264 | 1 | |c 2002 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 09.12.2002 | ||
| 500 | |a Date Revised 10.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The (4R)-hydroxylated analogues of annonaceous acetogenin mimicking compound 2 were designed and synthesized structurally on the basis of the naturally occurring annonaceous acetogenin bullatacin, which was discovered as a typical member of the novel family of polyketides with potent cytotoxicity, antitumoral, and other biological activities. The preliminary screenings show that the IC(50) values of 2 were 1.6 x 10(-3) and 8 x 10(-2) microg/mL against HT-29 and HCT-8, respectively. A remarkable enhancement effect was observed by the activity comparison of 1c and its (4R)-hydroxylated analogue 2 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a 3-((2R,13S)-2,13-dihydroxy-14-(2-(2S)-hydroxydodecyloxy)ethoxy)tetradecyl-5-methyl-5H-furan-2-one |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents, Phytogenic |2 NLM | |
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| 700 | 1 | |a Liu, Zhong-Hai |e verfasserin |4 aut | |
| 700 | 1 | |a Sheng, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Bu-Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Xiao-Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yu-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Zhu-Jun |e verfasserin |4 aut | |
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