A case report of allergic fungal sinusitis caused by Penicillium sp. and Cladosporium sp

We report a case of allergic fungal sinusitis (AFS) caused by Penicillium sp. and Cladosporium sp. in a 57-year-old man satisfying the following diagnostic criteria: (1) chronic rhinosinusitis revealed by computed tomographic scan, (2) Japanese cedar pollinosis for 3 years, (3) positivity for Penicillium sp. and Cladosporium sp. by a skin test, (4) increased immunoglobulin E (IgE) specific to these fungi, (5) increased total IgE, (6) nasal polyps with severe eosinophilic invasion, (7) allergic mucin revealed by histopathological examination, (8) fungal hyphae revealed by histopathological examination and (9) detection of Penicillium sp. and Cladosporium sp. revealed by fungi culture. The patient was treated by endoscopic sinus surgery. Four weeks after surgery, nasal polyps recurred, but his condition was improved by oral administration of steroids and nebulizer treatment with steroids and fluconazole. Total IgE, specific IgE and eosinophil count in the peripheral blood decreased, apparently reflecting this improvement. After obtaining the patient's consent, we conducted an allergen provocation test, which is as highly diagnostic as a skin test, to test for an antigen causing type I hypersensitivity. The immediate phase response was positive, indicating that type I hypersensitivity intermediated by IgE was involved in AFS.

Medienart:

Artikel

Erscheinungsjahr:

2001

Erschienen:

2001

Enthalten in:

Zur Gesamtaufnahme - volume:104

Enthalten in:

Nihon Jibiinkoka Gakkai kaiho - 104(2001), 12 vom: 05. Dez., Seite 1147-50

Sprache:

Japanisch

Beteiligte Personen:

Matsuwaki, Y [VerfasserIn]
Nakajima, T [VerfasserIn]
Iida, M [VerfasserIn]
Nohara, O [VerfasserIn]
Haruna, S [VerfasserIn]
Moriyama, H [VerfasserIn]

Themen:

37341-29-0
Case Reports
English Abstract
Immunoglobulin E
Journal Article

Anmerkungen:

Date Completed 13.02.2002

Date Revised 26.08.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM116907924