Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2002 |
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| Erschienen: |
2002 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:295 |
|---|---|
| Enthalten in: |
Science (New York, N.Y.) - 295(2002), 5554 vom: 18. Jan., Seite 502-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Arantes-Oliveira, Nuno [VerfasserIn] |
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| Themen: |
Caenorhabditis elegans Proteins |
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| Anmerkungen: |
Date Completed 08.02.2002 Date Revised 18.03.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Regulation of life-span by germ-line stem cells in Caenorhabditis elegans |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Caenorhabditis elegans Proteins |2 NLM | |
| 650 | 7 | |a Forkhead Transcription Factors |2 NLM | |
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| 650 | 7 | |a daf-16 protein, C elegans |2 NLM | |
| 700 | 1 | |a Apfeld, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Dillin, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Kenyon, Cynthia |e verfasserin |4 aut | |
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