Acute myocardial infarct in HIV-positive patients in treatment with protease inhibitors
We report the case of a 40-year-old HIV-positive man, undergoing three-drug antiretroviral therapy for 2 years that included a protease inhibitor (ritonavir). The patient was admitted to our Coronary Care Unit with an acute anterior myocardial infarction. He smoked 20 cigarettes/day and had a family history of hypertension. At the time of hospitalization, triglyceride levels were found to be high (290 mg/dl). Metabolic alterations associated with the prolonged use of protease inhibitors, such as insulin resistance, dyslipidemia and lipodystrophy, have recently been described. This side effect may lead to premature coronary artery disease. Therefore it is mandatory to be aware that treatment with protease inhibitors in HIV-positive patients, despite survival prolongation and lowering of AIDS complications, may accelerate atherosclerosis and precipitate acute coronary events, especially in patients with pre-existing cardiovascular risk factors.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2001 |
|---|---|
| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
|---|---|
| Enthalten in: |
Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology - 2(2001), 11 vom: 03. Nov., Seite 1236-9 |
| Sprache: |
Italienisch |
|---|
| Weiterer Titel: |
Infarto miocardico acuto in paziente HIV-positivo in trattamento con inibitori delle proteasi |
|---|
| Beteiligte Personen: |
Gurgo, A M [VerfasserIn] |
|---|
| Themen: |
Anti-HIV Agents |
|---|
| Anmerkungen: |
Date Completed 17.01.2002 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM116647752 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM116647752 | ||
| 003 | DE-627 | ||
| 005 | 20231222174755.0 | ||
| 007 | tu | ||
| 008 | 231222s2001 xx ||||| 00| ||ita c | ||
| 028 | 5 | 2 | |a pubmed24n0389.xml |
| 035 | |a (DE-627)NLM116647752 | ||
| 035 | |a (NLM)11775417 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a ita | ||
| 100 | 1 | |a Gurgo, A M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute myocardial infarct in HIV-positive patients in treatment with protease inhibitors |
| 246 | 3 | 3 | |a Infarto miocardico acuto in paziente HIV-positivo in trattamento con inibitori delle proteasi |
| 264 | 1 | |c 2001 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 17.01.2002 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We report the case of a 40-year-old HIV-positive man, undergoing three-drug antiretroviral therapy for 2 years that included a protease inhibitor (ritonavir). The patient was admitted to our Coronary Care Unit with an acute anterior myocardial infarction. He smoked 20 cigarettes/day and had a family history of hypertension. At the time of hospitalization, triglyceride levels were found to be high (290 mg/dl). Metabolic alterations associated with the prolonged use of protease inhibitors, such as insulin resistance, dyslipidemia and lipodystrophy, have recently been described. This side effect may lead to premature coronary artery disease. Therefore it is mandatory to be aware that treatment with protease inhibitors in HIV-positive patients, despite survival prolongation and lowering of AIDS complications, may accelerate atherosclerosis and precipitate acute coronary events, especially in patients with pre-existing cardiovascular risk factors | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anti-HIV Agents |2 NLM | |
| 650 | 7 | |a Reverse Transcriptase Inhibitors |2 NLM | |
| 650 | 7 | |a Stavudine |2 NLM | |
| 650 | 7 | |a BO9LE4QFZF |2 NLM | |
| 650 | 7 | |a Didanosine |2 NLM | |
| 650 | 7 | |a K3GDH6OH08 |2 NLM | |
| 650 | 7 | |a Ritonavir |2 NLM | |
| 650 | 7 | |a O3J8G9O825 |2 NLM | |
| 700 | 1 | |a Massino Ferri, F |e verfasserin |4 aut | |
| 700 | 1 | |a Iulianella, R |e verfasserin |4 aut | |
| 700 | 1 | |a Luciani, C |e verfasserin |4 aut | |
| 700 | 1 | |a Lucifero, A |e verfasserin |4 aut | |
| 700 | 1 | |a Staropoli, P |e verfasserin |4 aut | |
| 700 | 1 | |a Rocchi, M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology |d 2000 |g 2(2001), 11 vom: 03. Nov., Seite 1236-9 |w (DE-627)NLM106586602 |x 1129-4728 |7 nnns |
| 773 | 1 | 8 | |g volume:2 |g year:2001 |g number:11 |g day:03 |g month:11 |g pages:1236-9 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 2 |j 2001 |e 11 |b 03 |c 11 |h 1236-9 | ||