Both neurogenic and vascular causes of primary headache
The cerebral circulation is innervated by sympathetic, parasympathetic and sensory nerves which store a number of neurotransmitters. The significance of these for primary headache has been evaluated. A clear association between head pain and the release of calcitonin gene-related peptide (CGRP) was demonstrated. In cluster headache and in chronic paroxysmal hemicrania, there was additionally a release of vasoactive intestinal peptide (VIP) in association with facial symptoms (nasal congestion, rhinorrhea). Upon treatment with sumatriptan, head pain subsided and neuropeptide release normalized. These data show the involvement of sensory and parasympathetic mechanisms in the pathophysiology of primary headache.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2001 |
|---|---|
| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
|---|---|
| Enthalten in: |
Lakartidningen - 98(2001), 39 vom: 26. Sept., Seite 4176-83 |
| Sprache: |
Schwedisch |
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| Weiterer Titel: |
Både neurogena och vaskulära orsaker bakom primär huvudvärk |
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| Beteiligte Personen: |
Edvinsson, L [VerfasserIn] |
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| Themen: |
Calcium Channels |
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| Anmerkungen: |
Date Completed 04.12.2001 Date Revised 30.11.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM115745726 |
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| 245 | 1 | 0 | |a Both neurogenic and vascular causes of primary headache |
| 246 | 3 | 3 | |a Både neurogena och vaskulära orsaker bakom primär huvudvärk |
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| 500 | |a Date Completed 04.12.2001 | ||
| 500 | |a Date Revised 30.11.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The cerebral circulation is innervated by sympathetic, parasympathetic and sensory nerves which store a number of neurotransmitters. The significance of these for primary headache has been evaluated. A clear association between head pain and the release of calcitonin gene-related peptide (CGRP) was demonstrated. In cluster headache and in chronic paroxysmal hemicrania, there was additionally a release of vasoactive intestinal peptide (VIP) in association with facial symptoms (nasal congestion, rhinorrhea). Upon treatment with sumatriptan, head pain subsided and neuropeptide release normalized. These data show the involvement of sensory and parasympathetic mechanisms in the pathophysiology of primary headache | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Neurotransmitter Agents |2 NLM | |
| 650 | 7 | |a Receptors, Serotonin |2 NLM | |
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