Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells
Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to increase the number of tumor cells rather than their invasion or motility through the extracellular matrix. Estradiol is mitogenic but in vitro it also inhibits invasion and motility. In this review, we discuss the mechanism of this inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estrogens.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2001 |
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| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
|---|---|
| Enthalten in: |
The Journal of steroid biochemistry and molecular biology - 76(2001), 1-5 vom: 15. Jan., Seite 119-24 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rochefort, H [VerfasserIn] |
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| Themen: |
EC 3.4.- |
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| Anmerkungen: |
Date Completed 12.07.2001 Date Revised 01.09.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM112899463 |
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| 245 | 1 | 0 | |a Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells |
| 264 | 1 | |c 2001 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 12.07.2001 | ||
| 500 | |a Date Revised 01.09.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to increase the number of tumor cells rather than their invasion or motility through the extracellular matrix. Estradiol is mitogenic but in vitro it also inhibits invasion and motility. In this review, we discuss the mechanism of this inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estrogens | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Estrogens |2 NLM | |
| 650 | 7 | |a Protease Inhibitors |2 NLM | |
| 650 | 7 | |a Receptors, Estrogen |2 NLM | |
| 650 | 7 | |a Endopeptidases |2 NLM | |
| 650 | 7 | |a EC 3.4.- |2 NLM | |
| 700 | 1 | |a Chalbos, D |e verfasserin |4 aut | |
| 700 | 1 | |a Cunat, S |e verfasserin |4 aut | |
| 700 | 1 | |a Lucas, A |e verfasserin |4 aut | |
| 700 | 1 | |a Platet, N |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia, M |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:76 |g year:2001 |g number:1-5 |g day:15 |g month:01 |g pages:119-24 |
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