H+,K+-ATPase is not involved in endolymph pH homeostasis
In endolymph, the calculated electrochemical gradients suggest the presence of active transport of H+ and K+. The presence of H+,K+-ATPase, an active transporter that mediates the exchange of intracellular H+ for extracellular K+, was investigated using reverse transcription-polymerase chain reaction on rat microdissected inner ear tissues. Distal colon and kidney were used as positive controls. The two H+,K+-ATPase colonic or gastric isoforms were not detected in the rat cochlea and endolymphatic sac. This result suggests that H+,K+-ATPase is not involved in H+ and K+ endolymph homeostasis.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2001 |
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| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
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| Enthalten in: |
Acta oto-laryngologica - 121(2001), 2 vom: 15. Jan., Seite 122-4 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Couloigner, V [VerfasserIn] |
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| Themen: |
EC 7.2.2.13 |
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| Anmerkungen: |
Date Completed 18.10.2001 Date Revised 10.12.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM11256318X |
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| 245 | 1 | 0 | |a H+,K+-ATPase is not involved in endolymph pH homeostasis |
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| 500 | |a Date Completed 18.10.2001 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In endolymph, the calculated electrochemical gradients suggest the presence of active transport of H+ and K+. The presence of H+,K+-ATPase, an active transporter that mediates the exchange of intracellular H+ for extracellular K+, was investigated using reverse transcription-polymerase chain reaction on rat microdissected inner ear tissues. Distal colon and kidney were used as positive controls. The two H+,K+-ATPase colonic or gastric isoforms were not detected in the rat cochlea and endolymphatic sac. This result suggests that H+,K+-ATPase is not involved in H+ and K+ endolymph homeostasis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Sodium-Potassium-Exchanging ATPase |2 NLM | |
| 650 | 7 | |a EC 7.2.2.13 |2 NLM | |
| 700 | 1 | |a Teixeira, M |e verfasserin |4 aut | |
| 700 | 1 | |a Bozorg-Grayeli, A |e verfasserin |4 aut | |
| 700 | 1 | |a Friedlander, G |e verfasserin |4 aut | |
| 700 | 1 | |a Sterkers, O |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrary, E |e verfasserin |4 aut | |
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