p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation
The human positive coactivator 4 (PC4) acts as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation. We report here that PC4 can be acetylated specifically by another coactivator, p300. Interestingly, phosphorylation of PC4 by casein kinase II inhibits the p300-mediated acetylation. Mass spectral analysis revealed that there are at least two lysine residues acetylated in PC4, as a result of which its DNA binding activity is stimulated.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2001 |
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| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:276 |
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| Enthalten in: |
The Journal of biological chemistry - 276(2001), 20 vom: 18. Mai, Seite 16804-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, B R [VerfasserIn] |
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| Anmerkungen: |
Date Completed 05.07.2001 Date Revised 03.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM111888433 |
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| 008 | 231222s2001 xx ||||| 00| ||eng c | ||
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| 035 | |a (DE-627)NLM111888433 | ||
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| 041 | |a eng | ||
| 100 | 1 | |a Kumar, B R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation |
| 264 | 1 | |c 2001 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 05.07.2001 | ||
| 500 | |a Date Revised 03.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The human positive coactivator 4 (PC4) acts as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation. We report here that PC4 can be acetylated specifically by another coactivator, p300. Interestingly, phosphorylation of PC4 by casein kinase II inhibits the p300-mediated acetylation. Mass spectral analysis revealed that there are at least two lysine residues acetylated in PC4, as a result of which its DNA binding activity is stimulated | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Cell Cycle Proteins |2 NLM | |
| 650 | 7 | |a Histones |2 NLM | |
| 650 | 7 | |a IFRD2 protein, human |2 NLM | |
| 650 | 7 | |a Ifrd2 protein, mouse |2 NLM | |
| 650 | 7 | |a Immediate-Early Proteins |2 NLM | |
| 650 | 7 | |a Membrane Proteins |2 NLM | |
| 650 | 7 | |a Recombinant Proteins |2 NLM | |
| 650 | 7 | |a Repressor Proteins |2 NLM | |
| 650 | 7 | |a Saccharomyces cerevisiae Proteins |2 NLM | |
| 650 | 7 | |a Trans-Activators |2 NLM | |
| 650 | 7 | |a Transcription Factors |2 NLM | |
| 650 | 7 | |a Acetyltransferases |2 NLM | |
| 650 | 7 | |a EC 2.3.1.- |2 NLM | |
| 650 | 7 | |a Histone Acetyltransferases |2 NLM | |
| 650 | 7 | |a EC 2.3.1.48 |2 NLM | |
| 650 | 7 | |a p300-CBP Transcription Factors |2 NLM | |
| 650 | 7 | |a EC 2.3.1.48 |2 NLM | |
| 650 | 7 | |a p300-CBP-associated factor |2 NLM | |
| 650 | 7 | |a EC 2.3.1.48 |2 NLM | |
| 650 | 7 | |a Casein Kinase II |2 NLM | |
| 650 | 7 | |a EC 2.7.11.1 |2 NLM | |
| 650 | 7 | |a Protein Serine-Threonine Kinases |2 NLM | |
| 650 | 7 | |a EC 2.7.11.1 |2 NLM | |
| 650 | 7 | |a Lysine |2 NLM | |
| 650 | 7 | |a K3Z4F929H6 |2 NLM | |
| 700 | 1 | |a Swaminathan, V |e verfasserin |4 aut | |
| 700 | 1 | |a Banerjee, S |e verfasserin |4 aut | |
| 700 | 1 | |a Kundu, T K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of biological chemistry |d 1945 |g 276(2001), 20 vom: 18. Mai, Seite 16804-9 |w (DE-627)NLM000004995 |x 1083-351X |7 nnns |
| 773 | 1 | 8 | |g volume:276 |g year:2001 |g number:20 |g day:18 |g month:05 |g pages:16804-9 |
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| 951 | |a AR | ||
| 952 | |d 276 |j 2001 |e 20 |b 18 |c 05 |h 16804-9 | ||