Genetic and immunologic risks for development of type 1 diabetes--experiences from an intervention trial
BACKGROUND: Type 1 diabetes is a common multi-factorial disease. Recently, promising attempts have been made at preventing the disease in individuals at risk. We present our experiences as participants in an international multicentre intervention trial, the European Nicotinamide Diabetes Intervention Trial (ENDIT). The aim is to prevent prediabetic individuals from becoming overtly diabetic by the use of nicotinamide.
MATERIAL AND METHODS: First degree relatives of type 1 diabetes children attending paediatric clinics in Norway were recruited. The level of islet cell antibodies (ICA) was determined. Individuals with ICA titer above 20 Juvenile Diabetes Foundation Units (JDFU) were allocated to treatment with nicotinamide or placebo in a double-blind design. In the Norwegian patients in the trial HLA-DQ genotypes were also determined.
RESULTS: 56 individuals had ICA > 20 JDFU; 36 agreed to participate in the trial. Assessment of genetic and immunological risk did not seem to emotionally upset the majority of participants; so far, no serious adverse events have been observed. The final results of this trial are expected in year 2003.
INTERPRETATION: Prevention of type 1 diabetes may be feasible in the future.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2000 |
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| Erschienen: |
2000 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:120 |
|---|---|
| Enthalten in: |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 120(2000), 23 vom: 30. Sept., Seite 2799-803 |
| Sprache: |
Norwegisch |
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| Weiterer Titel: |
Genetisk og immunologisk risiko for type 1-diabetes--erfaringer fra en intervensjonsstudie. Norsk studiegruppe for barnediabetes |
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| Beteiligte Personen: |
Undlien, D E [VerfasserIn] |
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| Themen: |
25X51I8RD4 |
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| Anmerkungen: |
Date Completed 05.01.2001 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM110230868 |
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| 245 | 1 | 0 | |a Genetic and immunologic risks for development of type 1 diabetes--experiences from an intervention trial |
| 246 | 3 | 3 | |a Genetisk og immunologisk risiko for type 1-diabetes--erfaringer fra en intervensjonsstudie. Norsk studiegruppe for barnediabetes |
| 264 | 1 | |c 2000 | |
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| 500 | |a Date Completed 05.01.2001 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Type 1 diabetes is a common multi-factorial disease. Recently, promising attempts have been made at preventing the disease in individuals at risk. We present our experiences as participants in an international multicentre intervention trial, the European Nicotinamide Diabetes Intervention Trial (ENDIT). The aim is to prevent prediabetic individuals from becoming overtly diabetic by the use of nicotinamide | ||
| 520 | |a MATERIAL AND METHODS: First degree relatives of type 1 diabetes children attending paediatric clinics in Norway were recruited. The level of islet cell antibodies (ICA) was determined. Individuals with ICA titer above 20 Juvenile Diabetes Foundation Units (JDFU) were allocated to treatment with nicotinamide or placebo in a double-blind design. In the Norwegian patients in the trial HLA-DQ genotypes were also determined | ||
| 520 | |a RESULTS: 56 individuals had ICA > 20 JDFU; 36 agreed to participate in the trial. Assessment of genetic and immunological risk did not seem to emotionally upset the majority of participants; so far, no serious adverse events have been observed. The final results of this trial are expected in year 2003 | ||
| 520 | |a INTERPRETATION: Prevention of type 1 diabetes may be feasible in the future | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Genetic Markers |2 NLM | |
| 650 | 7 | |a HLA-DQ Antigens |2 NLM | |
| 650 | 7 | |a Niacinamide |2 NLM | |
| 650 | 7 | |a 25X51I8RD4 |2 NLM | |
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| 700 | 1 | |a Rønningen, K S |e verfasserin |4 aut | |
| 700 | 1 | |a Nicol-Smith, L |e verfasserin |4 aut | |
| 700 | 1 | |a Torjesen, P A |e verfasserin |4 aut | |
| 700 | 1 | |a Søvik, O |e verfasserin |4 aut | |
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