Influence of alpha-adrenoceptor blockade on antigen- and propranolol-induced bronchoconstriction in guinea-pigs in vivo
1. Beta-adrenoceptor antagonists, such as propranolol, can provoke severe bronchoconstriction only in asthmatic subjects. Recently, we developed a guinea-pig model of propranolol-induced bronchoconstriction (PIB) and the purpose of this study was to investigate the role of alpha-adrenergic nerve pathways in this reaction. 2. Phentolamine administered after an antigen challenge did not inhibit PIB; however, its administration before the antigen challenge significantly inhibited the antigen-induced bronchoconstriction and also bronchoconstriction induced by methacholine inhalation. 3. We conclude that the alpha-adrenergic nerve system is not involved in the development of PIB following allergic reaction in our guinea-pig model.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2000 |
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| Erschienen: |
2000 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Journal of autonomic pharmacology - 20(2000), 1 vom: 01. Feb., Seite 23-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ishiura, Y [VerfasserIn] |
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| Anmerkungen: |
Date Completed 22.02.2001 Date Revised 04.11.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM109660544 |
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| 100 | 1 | |a Ishiura, Y |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Influence of alpha-adrenoceptor blockade on antigen- and propranolol-induced bronchoconstriction in guinea-pigs in vivo |
| 264 | 1 | |c 2000 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 22.02.2001 | ||
| 500 | |a Date Revised 04.11.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a 1. Beta-adrenoceptor antagonists, such as propranolol, can provoke severe bronchoconstriction only in asthmatic subjects. Recently, we developed a guinea-pig model of propranolol-induced bronchoconstriction (PIB) and the purpose of this study was to investigate the role of alpha-adrenergic nerve pathways in this reaction. 2. Phentolamine administered after an antigen challenge did not inhibit PIB; however, its administration before the antigen challenge significantly inhibited the antigen-induced bronchoconstriction and also bronchoconstriction induced by methacholine inhalation. 3. We conclude that the alpha-adrenergic nerve system is not involved in the development of PIB following allergic reaction in our guinea-pig model | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Adrenergic alpha-Antagonists |2 NLM | |
| 650 | 7 | |a Adrenergic beta-Antagonists |2 NLM | |
| 650 | 7 | |a Antigens |2 NLM | |
| 650 | 7 | |a Bronchoconstrictor Agents |2 NLM | |
| 650 | 7 | |a Methacholine Chloride |2 NLM | |
| 650 | 7 | |a 0W5ETF9M2K |2 NLM | |
| 650 | 7 | |a Ovalbumin |2 NLM | |
| 650 | 7 | |a 9006-59-1 |2 NLM | |
| 650 | 7 | |a Propranolol |2 NLM | |
| 650 | 7 | |a 9Y8NXQ24VQ |2 NLM | |
| 650 | 7 | |a Phentolamine |2 NLM | |
| 650 | 7 | |a Z468598HBV |2 NLM | |
| 700 | 1 | |a Fujimura, M |e verfasserin |4 aut | |
| 700 | 1 | |a Myou, S |e verfasserin |4 aut | |
| 700 | 1 | |a Amemiya, T |e verfasserin |4 aut | |
| 700 | 1 | |a Nobata, K |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Q |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamori, C |e verfasserin |4 aut | |
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