Prothoracicotropic activity of SBRPs, the insulin-like peptides of the saturniid silkworm Samia cynthia ricini
Copyright 1999 Academic Press..
Synthesis and secretion of the insect molting hormone ecdysteroid in the prothoracic glands (PGs) are stimulated by the prothoracicotropic hormone (PTTH) secreted by the brain. Bombyxins, insulin-like peptides of the silkworm Bombyx mori, show prothoracicotropic activity when administered to the saturniid silkworm Samia cynthia ricini, but they are inactive to B. mori itself. Recently, the genes for the bombyxin homologs of S. cynthia ricini (referred to as Samia bombyxin-related peptides, SBRPs) were cloned. To examine the prothoracicotropic activity of SBRPs on S. cynthia ricini, we synthesized two representative molecules, SBRP-A1 and -B1. They promoted pupa-to-adult development with ED(50) of 50 and 10 ng/pupa (EC(50) of 5 and 1 nM), respectively.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1999 |
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| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:266 |
|---|---|
| Enthalten in: |
Biochemical and biophysical research communications - 266(1999), 2 vom: 20. Dez., Seite 575-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nagata, K [VerfasserIn] |
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| Themen: |
110098-88-9 |
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| Anmerkungen: |
Date Completed 18.01.2000 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM10530333X |
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| 100 | 1 | |a Nagata, K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prothoracicotropic activity of SBRPs, the insulin-like peptides of the saturniid silkworm Samia cynthia ricini |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 18.01.2000 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright 1999 Academic Press. | ||
| 520 | |a Synthesis and secretion of the insect molting hormone ecdysteroid in the prothoracic glands (PGs) are stimulated by the prothoracicotropic hormone (PTTH) secreted by the brain. Bombyxins, insulin-like peptides of the silkworm Bombyx mori, show prothoracicotropic activity when administered to the saturniid silkworm Samia cynthia ricini, but they are inactive to B. mori itself. Recently, the genes for the bombyxin homologs of S. cynthia ricini (referred to as Samia bombyxin-related peptides, SBRPs) were cloned. To examine the prothoracicotropic activity of SBRPs on S. cynthia ricini, we synthesized two representative molecules, SBRP-A1 and -B1. They promoted pupa-to-adult development with ED(50) of 50 and 10 ng/pupa (EC(50) of 5 and 1 nM), respectively | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Insect Hormones |2 NLM | |
| 650 | 7 | |a Neuropeptides |2 NLM | |
| 650 | 7 | |a Recombinant Fusion Proteins |2 NLM | |
| 650 | 7 | |a bombyxins |2 NLM | |
| 650 | 7 | |a 110098-88-9 |2 NLM | |
| 650 | 7 | |a prothoracicotropic hormone |2 NLM | |
| 650 | 7 | |a 61583-57-1 |2 NLM | |
| 700 | 1 | |a Maruyama, K |e verfasserin |4 aut | |
| 700 | 1 | |a Kojima, K |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, M |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, M |e verfasserin |4 aut | |
| 700 | 1 | |a Kataoka, H |e verfasserin |4 aut | |
| 700 | 1 | |a Nagasawa, H |e verfasserin |4 aut | |
| 700 | 1 | |a Isogai, A |e verfasserin |4 aut | |
| 700 | 1 | |a Ishizaki, H |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, A |e verfasserin |4 aut | |
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