Mitochondrial impact on nerve growth factor production in vascular smooth muscle-derived cells
Ht30</=Ht10>/=Ht5). Cells with reduced mitochondrial activity also showed abnormal responses to the stimulation of NGF output. Thrombin and phorbol ester elevated NGF production from Ht100, Ht30 and Ht10 cells, but not from Ht5 cells. Ht30 cells, despite secreting less NGF basally than Ht100 cells, reached a similar or greater NGF output upon stimulation. Mitogens increased NGF output and NGF mRNA levels with the largest effect on NGF protein in Ht30 cells. Free radical production and the ability of cells to respond to NGF-inducing agents were related. These data suggest that chronic impairment of mitochondrial function associates with disturbances in cellular production of a signaling protein.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1999 |
|---|---|
| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1473 |
|---|---|
| Enthalten in: |
Biochimica et biophysica acta - 1473(1999), 2-3 vom: 27. Dez., Seite 305-20 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sherer, T B [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 14.02.2000 Date Revised 10.06.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM105241636 |
|---|
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| 520 | |a Ht30</=Ht10>/=Ht5). Cells with reduced mitochondrial activity also showed abnormal responses to the stimulation of NGF output. Thrombin and phorbol ester elevated NGF production from Ht100, Ht30 and Ht10 cells, but not from Ht5 cells. Ht30 cells, despite secreting less NGF basally than Ht100 cells, reached a similar or greater NGF output upon stimulation. Mitogens increased NGF output and NGF mRNA levels with the largest effect on NGF protein in Ht30 cells. Free radical production and the ability of cells to respond to NGF-inducing agents were related. These data suggest that chronic impairment of mitochondrial function associates with disturbances in cellular production of a signaling protein | ||
| 650 | 4 | |a Comparative Study | |
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| 700 | 1 | |a Tuttle, J B |e verfasserin |4 aut | |
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