Intraoperative radiotherapy with accelerated electrons for urinary bladder carcinoma : principles and results
OBJECTIVE: To describe intraoperative radiotherapy with accelerated electrons, a highly selective method of administering irradiation for radical treatment of bladder cancer.
METHODS: We reviewed the experience reported in the literature since this treatment modality was utilized in Japan and its application extended to the western countries.
RESULTS: Animal experiments have shown an acceptable clinicopathological tolerance to 20 Gy intraoperative irradiation of partial bladder volume. The local recurrence rate was 9% for early solitary tumor (> T2) and 27% for early multicentric tumor, according to the Japanese clinical experience. In the western countries, intraoperative radiotherapy plus external irradiation with or without systemic chemotherapy achieves a pT0 of about 65% (in total cystectomy specimens) and an intravesical tumor control rate of 88% in organ-sparing protocols.
CONCLUSIONS: The results achieved by the groups with wider experience demonstrate that highly selective intraoperative radiotherapy is feasible, well-tolerated and effective in terms of inducing complete pathological remissions and definitive control of intravesical tumor. These selected clinical experiences must be corroborated by multicenter studies.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1999 |
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| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Archivos espanoles de urologia - 52(1999), 6 vom: 15. Juli, Seite 649-54 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Radioterapia intraoperatoria con electrones acelerados en el carcinoma de vejiga urinaria: fundamentos y resultados |
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| Beteiligte Personen: |
Calvo, F A [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 19.10.1999 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM104159251 |
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| 100 | 1 | |a Calvo, F A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Intraoperative radiotherapy with accelerated electrons for urinary bladder carcinoma |b principles and results |
| 246 | 3 | 3 | |a Radioterapia intraoperatoria con electrones acelerados en el carcinoma de vejiga urinaria: fundamentos y resultados |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 19.10.1999 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To describe intraoperative radiotherapy with accelerated electrons, a highly selective method of administering irradiation for radical treatment of bladder cancer | ||
| 520 | |a METHODS: We reviewed the experience reported in the literature since this treatment modality was utilized in Japan and its application extended to the western countries | ||
| 520 | |a RESULTS: Animal experiments have shown an acceptable clinicopathological tolerance to 20 Gy intraoperative irradiation of partial bladder volume. The local recurrence rate was 9% for early solitary tumor (> T2) and 27% for early multicentric tumor, according to the Japanese clinical experience. In the western countries, intraoperative radiotherapy plus external irradiation with or without systemic chemotherapy achieves a pT0 of about 65% (in total cystectomy specimens) and an intravesical tumor control rate of 88% in organ-sparing protocols | ||
| 520 | |a CONCLUSIONS: The results achieved by the groups with wider experience demonstrate that highly selective intraoperative radiotherapy is feasible, well-tolerated and effective in terms of inducing complete pathological remissions and definitive control of intravesical tumor. These selected clinical experiences must be corroborated by multicenter studies | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Aristu, J |e verfasserin |4 aut | |
| 700 | 1 | |a Azinovic, I |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, R |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, M |e verfasserin |4 aut | |
| 700 | 1 | |a Ortiz de Urbina, D |e verfasserin |4 aut | |
| 700 | 1 | |a Berián, J M |e verfasserin |4 aut | |
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