Relation between metabolism of trace elements and the antioxidant defense system in chronic nephropathies
BACKGROUND: Trace elements--zinc, copper and selenium are part of antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GHPx). In renal diseases changes in the trace element metabolism may influence the equilibrium in the antioxidant defence system and enhance the toxic effect of reactive oxygen molecules.
METHODS AND RESULTS: The authors examined in 53 children with chronic neprophathies (34 with chronic glomerulonephritis, 11 with chronic renal failure and 8 children included in a chronic dialyzation programme) zinc and selenium in blood and urine and antioxidant enzymes SOD and GHPx in red blood cells. The lowest SOD activity (737 +/- 219 U/g Hb, p < 0.01) and serum zinc concentration (12.9 +/- 3.2, p < 0.05) were found in children in the terminal stage of uraemia, GHPx was as compared with the group of healthy children elevated in all groups of sick children. In dialysed children GHPx was highest (p < 0.01) and correlated with urinary selenium concentrations (r = -0.86, p < 0.05). The SOD activity depended on the serum copper concentrations (r = 0.78, p < 0.05). The highest renal zinc and selenium excretion was recorded in patients with glomerulonephritis (p < 0.05).
CONCLUSIONS: The results support the hypothesis on a causal relationship between trace elements and antioxidant enzymes.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1999 |
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| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:138 |
|---|---|
| Enthalten in: |
Casopis lekaru ceskych - 138(1999), 11 vom: 24. Mai, Seite 337-9 |
| Sprache: |
Slowakisch |
|---|
| Weiterer Titel: |
Vztah medzi metabolizmom stopových prvkov a obranným antioxidacným systémom pri chronických nefropatiách |
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| Beteiligte Personen: |
Podracká, L [VerfasserIn] |
|---|
| Themen: |
Antioxidants |
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| Anmerkungen: |
Date Completed 24.08.1999 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM103540083 |
|---|
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|---|---|---|---|
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| 003 | DE-627 | ||
| 005 | 20231222130611.0 | ||
| 007 | tu | ||
| 008 | 231222s1999 xx ||||| 00| ||slo c | ||
| 028 | 5 | 2 | |a pubmed24n0346.xml |
| 035 | |a (DE-627)NLM103540083 | ||
| 035 | |a (NLM)10422345 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a slo | ||
| 100 | 1 | |a Podracká, L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Relation between metabolism of trace elements and the antioxidant defense system in chronic nephropathies |
| 246 | 3 | 3 | |a Vztah medzi metabolizmom stopových prvkov a obranným antioxidacným systémom pri chronických nefropatiách |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 24.08.1999 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Trace elements--zinc, copper and selenium are part of antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GHPx). In renal diseases changes in the trace element metabolism may influence the equilibrium in the antioxidant defence system and enhance the toxic effect of reactive oxygen molecules | ||
| 520 | |a METHODS AND RESULTS: The authors examined in 53 children with chronic neprophathies (34 with chronic glomerulonephritis, 11 with chronic renal failure and 8 children included in a chronic dialyzation programme) zinc and selenium in blood and urine and antioxidant enzymes SOD and GHPx in red blood cells. The lowest SOD activity (737 +/- 219 U/g Hb, p < 0.01) and serum zinc concentration (12.9 +/- 3.2, p < 0.05) were found in children in the terminal stage of uraemia, GHPx was as compared with the group of healthy children elevated in all groups of sick children. In dialysed children GHPx was highest (p < 0.01) and correlated with urinary selenium concentrations (r = -0.86, p < 0.05). The SOD activity depended on the serum copper concentrations (r = 0.78, p < 0.05). The highest renal zinc and selenium excretion was recorded in patients with glomerulonephritis (p < 0.05) | ||
| 520 | |a CONCLUSIONS: The results support the hypothesis on a causal relationship between trace elements and antioxidant enzymes | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Trace Elements |2 NLM | |
| 650 | 7 | |a Glutathione Peroxidase |2 NLM | |
| 650 | 7 | |a EC 1.11.1.9 |2 NLM | |
| 650 | 7 | |a Superoxide Dismutase |2 NLM | |
| 650 | 7 | |a EC 1.15.1.1 |2 NLM | |
| 650 | 7 | |a Selenium |2 NLM | |
| 650 | 7 | |a H6241UJ22B |2 NLM | |
| 650 | 7 | |a Zinc |2 NLM | |
| 650 | 7 | |a J41CSQ7QDS |2 NLM | |
| 700 | 1 | |a Sasinka, M |e verfasserin |4 aut | |
| 700 | 1 | |a Rácz, O |e verfasserin |4 aut | |
| 700 | 1 | |a Sipulová, A |e verfasserin |4 aut | |
| 700 | 1 | |a Gayová, E |e verfasserin |4 aut | |
| 700 | 1 | |a Horská, M |e verfasserin |4 aut | |
| 700 | 1 | |a Boor, A |e verfasserin |4 aut | |
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| 952 | |d 138 |j 1999 |e 11 |b 24 |c 05 |h 337-9 | ||