Chronic myeloid leukemia in health regions 1, 3, 4 and 5 during the period 1990-96
The aim of the present investigation was to obtain information about treatment, clinical course and outcome for all patients with chronic myeloid leukaemia through a six-year period in a defined part of Norway. A total number of 141 patients fulfilled the diagnostic criteria. This is equivalent to 0.9 patients per 100,000 per year. The median age was 62 years. More than 70% of the patients were primarily treated with hydroxyurea, either alone or combined with interferon. 40 out of 57 patients younger than 55 years underwent allogeneic stem cell transplantation. Median survival for all patients was 36 months with an estimated five-year survival rate of 33%. Patients older than 55 years had a median survival of 30 months with 16% alive after five years. The five-year survival rate for patients younger than 55 years was 56%, for transplanted patients 72%. 60 of 84 patients older than 55 years have died after 4 1/2 years median observation time. Two thirds of those died of leukaemia; one third of other causes. 23 of 57 patients younger than 55 years have died. 11 of them had had transplantations and most of them died from transplantation-related causes, while leukaemia was the dominating cause of death in the others.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1999 |
|---|---|
| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
|---|---|
| Enthalten in: |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 119(1999), 12 vom: 10. Mai, Seite 1733-6 |
| Sprache: |
Norwegisch |
|---|
| Weiterer Titel: |
Kronisk myelogen leukemi i helseregion 1, 3, 4 og 5 i perioden 1990-96 |
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| Beteiligte Personen: |
Lamvik, J [VerfasserIn] |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 07.07.1999 Date Revised 16.07.2008 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM103126961 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
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| 100 | 1 | |a Lamvik, J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chronic myeloid leukemia in health regions 1, 3, 4 and 5 during the period 1990-96 |
| 246 | 3 | 3 | |a Kronisk myelogen leukemi i helseregion 1, 3, 4 og 5 i perioden 1990-96 |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 07.07.1999 | ||
| 500 | |a Date Revised 16.07.2008 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The aim of the present investigation was to obtain information about treatment, clinical course and outcome for all patients with chronic myeloid leukaemia through a six-year period in a defined part of Norway. A total number of 141 patients fulfilled the diagnostic criteria. This is equivalent to 0.9 patients per 100,000 per year. The median age was 62 years. More than 70% of the patients were primarily treated with hydroxyurea, either alone or combined with interferon. 40 out of 57 patients younger than 55 years underwent allogeneic stem cell transplantation. Median survival for all patients was 36 months with an estimated five-year survival rate of 33%. Patients older than 55 years had a median survival of 30 months with 16% alive after five years. The five-year survival rate for patients younger than 55 years was 56%, for transplanted patients 72%. 60 of 84 patients older than 55 years have died after 4 1/2 years median observation time. Two thirds of those died of leukaemia; one third of other causes. 23 of 57 patients younger than 55 years have died. 11 of them had had transplantations and most of them died from transplantation-related causes, while leukaemia was the dominating cause of death in the others | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 700 | 1 | |a Brinch, L |e verfasserin |4 aut | |
| 700 | 1 | |a Dahl, I M |e verfasserin |4 aut | |
| 700 | 1 | |a Sjo, M |e verfasserin |4 aut | |
| 700 | 1 | |a Nesthus, I |e verfasserin |4 aut | |
| 700 | 1 | |a Tangen, J M |e verfasserin |4 aut | |
| 700 | 1 | |a Berentsen, S |e verfasserin |4 aut | |
| 700 | 1 | |a Ly, B |e verfasserin |4 aut | |
| 700 | 1 | |a Shammas, F V |e verfasserin |4 aut | |
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