Comparative trial of artificial and natural surfactants in the treatment of respiratory distress syndrome of prematurity : experiences in a developing country
We conducted a randomized clinical trial to compare the effects of a synthetic (Exosurf) and natural (Survanta) surfactant in infants with neonatal respiratory distress syndrome. Eighty-nine patients were randomly allocated to receive one of the two surfactants. Primary outcome variables were the acute and long-term effects of the surfactant preparations, i.e., ventilatory requirements at 24 h of age as judged by the oxygenation index (OI), and the combined incidence of chronic lung disease or death at 28 days. The OIs in the Exosurf and Survanta groups at 24 h were the same (10.1 and 7, respectively; P > 0.05). The magnitude and rapidity of response, however, were greater for Survanta than for Exosurf. When arterial/alveolar oxygen tension ratios (a/A) were compared, the Exosurf group had a significantly worse a/A ratio at 24 h than the Survanta group (0.21 Exosurf vs. 0.37 Survanta; P < 0.05). The long-term outcome as judged by the combined incidence of death or chronic lung disease was not different in the two groups (18.6% Exosurf vs. 15.2% Survanta; P > 0.05). When the complications of prematurity were compared, there were no statistically significant differences between the two groups. We conclude that both preparations are reasonable choices for the treatment of respiratory distress syndrome of prematurity.
| Errataetall: |
CommentIn: Pediatr Pulmonol. 1999 May;27(5):303-4. - PMID 10344707 |
|---|---|
| Medienart: |
Artikel |
| Erscheinungsjahr: |
1999 |
|---|---|
| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
|---|---|
| Enthalten in: |
Pediatric pulmonology - 27(1999), 5 vom: 01. Mai, Seite 312-7 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
da Costa, D E [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 15.07.1999 Date Revised 15.09.2019 published: Print CommentIn: Pediatr Pulmonol. 1999 May;27(5):303-4. - PMID 10344707 Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM102770662 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM102770662 | ||
| 003 | DE-627 | ||
| 005 | 20231222124942.0 | ||
| 007 | tu | ||
| 008 | 231222s1999 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0343.xml |
| 035 | |a (DE-627)NLM102770662 | ||
| 035 | |a (NLM)10344709 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a da Costa, D E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparative trial of artificial and natural surfactants in the treatment of respiratory distress syndrome of prematurity |b experiences in a developing country |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 15.07.1999 | ||
| 500 | |a Date Revised 15.09.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Pediatr Pulmonol. 1999 May;27(5):303-4. - PMID 10344707 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We conducted a randomized clinical trial to compare the effects of a synthetic (Exosurf) and natural (Survanta) surfactant in infants with neonatal respiratory distress syndrome. Eighty-nine patients were randomly allocated to receive one of the two surfactants. Primary outcome variables were the acute and long-term effects of the surfactant preparations, i.e., ventilatory requirements at 24 h of age as judged by the oxygenation index (OI), and the combined incidence of chronic lung disease or death at 28 days. The OIs in the Exosurf and Survanta groups at 24 h were the same (10.1 and 7, respectively; P > 0.05). The magnitude and rapidity of response, however, were greater for Survanta than for Exosurf. When arterial/alveolar oxygen tension ratios (a/A) were compared, the Exosurf group had a significantly worse a/A ratio at 24 h than the Survanta group (0.21 Exosurf vs. 0.37 Survanta; P < 0.05). The long-term outcome as judged by the combined incidence of death or chronic lung disease was not different in the two groups (18.6% Exosurf vs. 15.2% Survanta; P > 0.05). When the complications of prematurity were compared, there were no statistically significant differences between the two groups. We conclude that both preparations are reasonable choices for the treatment of respiratory distress syndrome of prematurity | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Age Factors | |
| 650 | 4 | |a Arab Countries | |
| 650 | 4 | |a Asia | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Clinical Research | |
| 650 | 4 | |a Comparative Studies | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Developing Countries | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a Infant | |
| 650 | 4 | |a Neonatal Diseases And Abnormalities | |
| 650 | 4 | |a Oman | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population Characteristics | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Pregnancy Outcomes | |
| 650 | 4 | |a Premature Birth | |
| 650 | 4 | |a Pulmonary Effects | |
| 650 | 4 | |a Reproduction | |
| 650 | 4 | |a Research Methodology | |
| 650 | 4 | |a Research Report | |
| 650 | 4 | |a Respiratory Insufficiency | |
| 650 | 4 | |a Studies | |
| 650 | 4 | |a Treatment | |
| 650 | 4 | |a Western Asia | |
| 650 | 4 | |a Youth | |
| 650 | 7 | |a Biological Products |2 NLM | |
| 650 | 7 | |a Drug Combinations |2 NLM | |
| 650 | 7 | |a Fatty Alcohols |2 NLM | |
| 650 | 7 | |a Pulmonary Surfactants |2 NLM | |
| 650 | 7 | |a Phosphorylcholine |2 NLM | |
| 650 | 7 | |a 107-73-3 |2 NLM | |
| 650 | 7 | |a Polyethylene Glycols |2 NLM | |
| 650 | 7 | |a 3WJQ0SDW1A |2 NLM | |
| 650 | 7 | |a dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination |2 NLM | |
| 650 | 7 | |a 99732-49-7 |2 NLM | |
| 650 | 7 | |a beractant |2 NLM | |
| 650 | 7 | |a S866O45PIG |2 NLM | |
| 700 | 1 | |a Pai, M G |e verfasserin |4 aut | |
| 700 | 1 | |a Al Khusaiby, S M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric pulmonology |d 1993 |g 27(1999), 5 vom: 01. Mai, Seite 312-7 |w (DE-627)NLM012888230 |x 1099-0496 |7 nnns |
| 773 | 1 | 8 | |g volume:27 |g year:1999 |g number:5 |g day:01 |g month:05 |g pages:312-7 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 27 |j 1999 |e 5 |b 01 |c 05 |h 312-7 | ||